15 results found
    1. Ecology

    Volatile DMNT directly protects plants against Plutella xylostella by disrupting the peritrophic matrix barrier in insect midgut

    Chen Chen, Hongyi Chen ... Peijin Li
    The natural volatile component DMNT protects plants from insect attacks by damaging peritropic matrix barriers in insect midguts, paving a promising way for the molecular breeding of plant protection.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

    Nadja S Katheder, Kristen C Browder ... Heinrich Jasper
    Signaling through nicotinic acetylcholine receptors in enterocytes impacts barrier integrity in the Drosophila intestine by regulating formation of the peritrophic matrix.
    1. Physics of Living Systems

    Developmental adaptations of trypanosome motility to the tsetse fly host environments unravel a multifaceted in vivo microswimmer system

    Sarah Schuster, Timothy Krüger ... Markus Engstler
    Trypanosome development within the transmitting tsetse fly reveals essential adaptations of microbial motility to diverse physical microenvironments.
    1. Microbiology and Infectious Disease

    Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against Plasmodium

    Ana Beatriz F Barletta, Banhisikha Saha ... Carolina Barillas-Mury
    Toll signaling modulates hemocyte differentiation into the megacyte lineage and their recruitment to the midgut greatly enhances mosquito immunity against Plasmodium.
    1. Genetics and Genomics

    Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

    Astrid Hoermann, Sofia Tapanelli ... Nikolai Windbichler
    Minimal genetic modifications of endogenous mosquito genes allow the tissue-specific expression of anti-malarial effectors and convert them into efficient non-autonomous gene drives.
    1. Structural Biology and Molecular Biophysics

    Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

    Xiaomei Sun, Yuxin Ye ... Min Yao
    A structural and biochemical study reveals the molecular mechanism of the predator–prey associations of Aplysia kurodai and brown algae (akuBGL–phlorotannin/laminarin–EHEP system), which has high-potential applications in the biotechnology industry.
    1. Microbiology and Infectious Disease

    Unexpected plasticity in the life cycle of Trypanosoma brucei

    Sarah Schuster, Jaime Lisack ... Markus Engstler
    Parasite life cycles may be more flexible than traditionally thought, potentially allowing single-cell infections of insect vectors and transmission between hosts even at very low parasite densities.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

    Bretta Hixson, Xiao-Li Bing ... Nicolas Buchon
    RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D

    Rachel V Stadler, Shane R Nelson ... Gary E Ward
    Parasites constrict as they propel themselves through the extracellular matrix one body length at a time, in a process highly reminiscent of host cell invasion.
    1. Structural Biology and Molecular Biophysics

    Subdued, a TMEM16 family Ca2+-activated Cl channel in Drosophila melanogaster with an unexpected role in host defense

    Xiu Ming Wong, Susan Younger ... Lily Y Jan
    A newly characterized calcium-activated chloride channel has been implicated in the immune system of Drosophila, shedding light on an enigmatic family of transmembrane proteins that are ubiquitous in nature.

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