9,804 results found
    1. Ecology

    Global gradients in intertidal species richness and functional groups

    Jakob Thyrring, Lloyd S Peck
    No discernible latitudinal diversity gradient in rocky intertidal α-diversity as local-scale physical and biological processes outweigh global-scale environmental gradients.
    1. Microbiology and Infectious Disease

    A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii

    Jaeeun Park et al.
    Outer membrane vesicles serve as decoys to reduce the chance of direct polymyxin B (PMB) binding to cells, which partly explains why many clinical isolates and microbial communities can be protected against PMB treatment.
    1. Structural Biology and Molecular Biophysics

    Structure of the CLC-1 chloride channel from Homo sapiens

    Eunyong Park, Roderick MacKinnon
    A cryo-electron microscopy study of the human CLC-1 chloride ion channel reveals the structural basis of why some CLC proteins function as passive chloride channels whereas others function as an active proton-chloride antiporters.
    1. Immunology and Inflammation

    Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

    Eugene Park et al.
    Toxoplasma gondii infection leads to conversion of natural killer cells into cells resembling innate lymphoid cells, group 1, that circulate widely, disrupting current notions suggesting that these cells have distinct lineages.
    1. Ecology
    2. Evolutionary Biology

    Why is cyclic dominance so rare?

    Hye Jin Park et al.
    A mathematical model for a popular biological diversity mechanism, cyclic dominance, is more likely to emerge by assembly than by evolutionary diversification, which rationalizes why few empirically studies find it.
    1. Computational and Systems Biology
    2. Neuroscience

    Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction

    Nadiatou T Miningou Zobon et al.
    ERK activation during induction of long-term synaptic plasticity is enhanced by synergistic interactions among signaling pathways mediated by the synaptically located GTPase-activating protein, and each pathway contributes to different ERK temporal dynamics.
    1. Cell Biology

    Cavin-3 dictates the balance between ERK and Akt signaling

    Victor J Hernandez et al.
    Cavin-3 is a tumor suppressor protein that inhibits Akt signaling, suppresses Warburg metabolism, promotes apoptosis, and protects against cachexia.
    1. Structural Biology and Molecular Biophysics

    De novo design of a homo-trimeric amantadine-binding protein

    Jooyoung Park et al.
    The first successful de novo design of a homo-trimeric protein that binds a C3 symmetric small molecule larger than a metal ion is an advance for computational protein design.
    1. Cell Biology
    2. Genetics and Genomics

    KPNB1 mediates PER/CRY nuclear translocation and circadian clock function

    Yool Lee et al.
    KPNB1 regulates rhythmic spatio-temporal nuclear import of the PER/CRY complex and is required for negative feedback repression in mammalian and fly clock function.
    1. Neuroscience

    Shared neural underpinnings of multisensory integration and trial-by-trial perceptual recalibration in humans

    Hame Park, Christoph Kayser
    Facing discrepancies in the sensory environment, multisensory information is combined in the medial superior parietal cortex to guide immediate judgements and to also adjust subsequent unisensory perception.

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