356 results found
    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    Modulation of occluding junctions alters the hematopoietic niche to trigger immune activation

    Rohan J Khadilkar et al.
    Occluding-junctions form a permeability barrier around the hematopoietic niche in Drosophila that controls the production of immune cells in response to infection by shaping the signalling micro-environment produced by the niche.
    1. Neuroscience

    Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

    Mette Mathiesen Janiurek et al.
    Shortage of blood-borne apolipoprotein-M–bound sphingosine-1-phosphate, which accompanies various brain disorders, causes paracellular leak and increase in transcytosis at the blood–brain barrier, which can be reversed, thus is of clinical relevance.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Investigating molecular crowding within nuclear pores using polarization-PALM

    Guo Fu et al.
    The super-resolution fluorescence microscopy approach polarization PALM (p-PALM) reveals that macromolecular crowding and inhomogeneity within nuclear pores generate a structurally and dynamically complex permeability barrier.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity

    Hermann Broder Schmidt, Dirk Görlich
    How nuclear pore complexes establish their permeability barrier has been a long-standing question; now, this process can be reconstituted by a surprisingly simple and rapid self-assembly of Nup98 FG domains into selective FG phases.
    1. Structural Biology and Molecular Biophysics

    Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

    Adithya N Ananth et al.
    Biomimetic nanopores reveal that the sequence-dependent spatial distribution of intrinsically disordered proteins plays a crucial role in establishing the selective permeability barrier of the nuclear pore complex.
    1. Cancer Biology

    Philosophy of Biology: Characterizing causality in cancer

    Elena Rondeau et al.
    Ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body.
    1. Developmental Biology

    Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

    Yi Xin et al.
    Genetics, in vivo imaging, and unbiased chemical biology screens reveal that Trpv6 functions as a cellular quiescence regulator and delineates a Trpv6-mediated Ca2+ signaling pathway maintaining the quiescent state.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

    Wenlei Ye et al.
    TMEM16F shifts its ion selectivity in response to change of intracellular Ca2+, membrane potential and ionic strength.
    1. Neuroscience

    Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

    Jordan N Norwood et al.
    Chemical ablation of olfactory sensory neurons blocks cerebrospinal fluid outflow into the nasal epithelium, leading to alterations of cerebrospinal fluid dynamics.

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