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865 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria

    Asha Mary Joseph et al.
    Live-cell imaging shows that replication-independent specialized polymerase action is a consequence of lesion processing via NER and impacts cellular survival under stress outside replicative phases of the cell cycle.
    1. Cancer Biology
    2. Developmental Biology

    An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

    Rediet Zewdu et al.
    Genetically engineered murine models reveal novel mechanisms of cell identity regulation in lung cancer and provide insights into the complex interplay between lineage specifiers and oncogenic signaling pathways in this disease.
    1. Developmental Biology

    The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling

    Shi-Li Xia et al.
    Identified as a binding factor of transcription factor MYRF, the LRR-TM protein PAN-1 promotes the cell-membrane localization and nuclear translocation of MYRF, which drives synaptic rewiring in Caenorhabditis elegans.
    1. Developmental Biology

    Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development

    Markus Frederik Schliffka et al.
    During mouse preimplantation development, the complete loss of actomyosin contractility abolishes cytokinesis but not apico-basal polarisation, lineage specification, or fluid accumulation, which are the critical steps to the formation of the blastocyst.
    1. Ecology
    2. Microbiology and Infectious Disease

    Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America

    Rita de Cassia Pessotti et al.
    The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
    1. Genetics and Genomics

    Whole-genome sequencing analysis of semi-supercentenarians

    Paolo Garagnani et al.
    Genetic variants located in DNA repair genes and a reduced burden of somatic mutations protect the oldest living persons from age-related diseases, allowing an healthy aging phenotype.
    1. Neuroscience

    Visualizing anatomically registered data with brainrender

    Federico Claudi et al.
    Brainrender is an open-source and user-friendly software for combining any type of anatomically registered data into custom interactive 3D renderings.
    1. Microbiology and Infectious Disease

    Repeated introductions and intensive community transmission fueled a mumps virus outbreak in Washington State

    Louise H Moncla et al.
    Social networks can be the primary risk factor for mumps infection and transmission, regardless of age and vaccination status.
    1. Immunology and Inflammation
    2. Medicine

    Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life

    Rozlyn CT Boutin et al.
    Overgrowth of the yeast Pichia kudriavzevii within the neonatal gut microbiota increases allergic airway disease severity later in life and may be inhibited by short-chain fatty acids.
    1. Cell Biology
    2. Physics of Living Systems

    Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

    Manuel Giménez-Andrés et al.
    The amphipathic helix of perilipin 4 relies on the organization of its polar residues to form a remarkably immobile and stable protein layer on the surface of lipid droplets.

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