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A new framework for examining tolerance in the context of quorum-sensing that may ultimately help predict and manage bacterial tolerance and, therefore, improve clinical outcome during infection.

Engineered mesenchymal stem cells (MSCs) could produce mutant β-galactosidase and trigger nitric oxide (NO) release when the NO prodrug is systemically administered, which can achieve NO release in a precise spatiotemporal manner and augment the therapeutic efficiency of MSCs.

Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.

Distinct interactions of AP endonuclease 1 with single-stranded DNA gaps and ATRIP and RPA protein complex address an outstanding question in the field of genome integrity regarding how ATR/ATRIP complex recruits onto damage site for ATR DNA damage response signaling.

The cryo-EM structure of a functional human NOX2-p22 complex in nanodisc in the resting state reveals the architecture of this key enzyme essential for innate immunity.

Strains of the bacterium Pseudomonas aeruginosa that use secondary metabolism to make surfactants and change the surface tension of the liquid that surrounds them do so only if they can first meet their primary metabolic needs.

C. elegans nematodes can assess faithfully the threat that H₂O₂ poses by coupling the induction of their H₂O₂ defenses to the perception of high temperature—an inherent enhancer of the reactivity of H₂O₂.

The repair of oxidatively damaged proteins by the newly discovered activity in YjbI is important for the adaptation of Bacillus subtilis to oxidative environments.