168 results found
    1. Cell Biology

    Adiponectin preserves metabolic fitness during aging

    Na Li et al.
    Adiponectin is an essential regulator for healthspan and is indispensable for sustaining a normal lifespan.
    1. Immunology and Inflammation
    2. Neuroscience

    Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

    Sina C Rosenkranz et al.
    Inducing neuronal mitochondrial activity during central nervous system inflammation counteracts inflammation-induced neuronal electron transport chain deficiency and calcium toxicity, thereby protecting against neuronal loss in a multiple sclerosis mouse model.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland et al.
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Proximity proteomics in a marine diatom reveals a putative cell surface-to-chloroplast iron trafficking pathway

    Jernej Turnšek et al.
    An iron-sensitive gene cluster encodes proteins that co-localize with phytotransferrin endosomes and are involved in key intracellular iron transformation and trafficking processes in a model marine diatom.
    1. Neuroscience

    Drp1 is required for AgRP neuronal activity and feeding

    Sungho Jin et al.
    Mitochondrial fission, associated with fatty acids oxidation, is fundamental for AgRP neuronal activity during negative energy balance and in regulating fasting- and/or ghrelin-induced feeding.
    1. Plant Biology

    A multifaceted analysis reveals two distinct phases of chloroplast biogenesis during de-etiolation in Arabidopsis

    Rosa Pipitone et al.
    Serial-Block-Face Scanning Electron Microscopy (SBF-SEM) associated with biomolecular analysis show that chloroplast differentiation proceeds by distinct ‘structure establishment’ and ‘chloroplast proliferation’ phases, each with differential protein and lipid regulation.
    1. Immunology and Inflammation

    Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

    Rabina Mainali et al.
    Integrative multi-omics reveals global dysregulation in hepatic metabolism during prolonged sepsis.
    1. Biochemistry and Chemical Biology

    Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway

    Jian Dai et al.
    Curcumin regulates gene expression via PPARa activation and exhibits biological activities involved in amyloidosis, peroxisome proliferation, lipid metabolism, and hepatocyte hypertrophy.
    1. Cell Biology

    TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

    Fernando R Balestra et al.
    TRIM37 prevents the formation of centriolar protein assemblies through an atypical de novo assembly pathway that would otherwise threaten genome integrity.
    1. Developmental Biology
    2. Genetics and Genomics

    Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

    Jason W Millington et al.
    The ability to adjust body size in response to diet is greater in Drosophila females than males because of a sex difference in the nutrient-dependent regulation of the insulin pathway.

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