Continuous perioperative IFNα therapy stimulates hepatic endothelial cells to build up physical vascular barrier that limits tumor cell entry into the liver and promotes long-term antitumor immunity.

Arp2/3 complex-mediated actin polymerization shapes how B lymphocytes probe the surface of antigen-presenting cells, promotes coalescence of B cell receptor (BCR) microclusters, amplifies BCR signaling, and enhances B cell activation.

Disruption of quality control pathways that function at distinct steps to mitigate errors in translation evoke similar cellular responses and pathologies.

A continuously expressed LIM HD factor, Lmx1b, acts at successive stages to orchestrate the progressive morphological maturation of a long-range profusely arborized neuromodulatory axonal projection pathway.

Muscle stem cells locally respond to perturbations of motor neurons and the neuromuscular junction.

Site-specific phosphorylation of the A-kinase anchoring protein 12 (AKAP12) in hepatic stellate cells modulates its scaffolding function and promotes liver fibrosis.

TEAD1 is a major partner transcription factor of YAP/TAZ crucial for developmental myelination and remyelination of peripheral nerves.

Pup-On-target for Small molecule Target Identification Technology, POST-IT, is a revolutionary tool for accurately identifying protein targets of bioactive molecules in living cells and organisms, successfully identifying SEPHS2 and VPS37C as targets for dasatinib and hydroxychloroquine, respectively.

Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.

Pituitary gland size and stem cell number is modulated during early life in the mouse by the imprinted gene Dlk1, which acts in multiple developmental compartments in a dosage-sensitive manner.