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A gradient of Wnt activity positions the neurosensory domains of the inner ear
Magdalena Żak, Nicolas Daudet
Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.
Immunology and Inflammation
Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism
Leonie Zeitler et al.
IL4i1 is an amino acid oxidase expressed in the mammalian immune system and snake venoms, which control diametrically opposite cell protection versus cell death pathways, respectively.
SUMO is a pervasive regulator of meiosis
Nikhil R Bhagwat et al.
Multi-dimensional global proteomics describes the SUMO-modified proteome during meiosis and reveals novel roles in regulating the key events of meiotic chromosome metabolism.
Physics of Living Systems
Swarming bacteria undergo localized dynamic phase transition to form stress-induced biofilms
Iago Grobas et al.
Collective stress response via localized dynamic phase transition turns swarming
Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response
Matthew D Keefe et al.
Neurological pathology and chronic activation of the induced stress response are caused by expression of a truncated EIF2B5 in vanishing white matter disease.
Computational and Systems Biology
Cell-cycle-gated feedback control mediates desensitization to interferon stimulation
Anusorn Mudla et al.
Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.
Stem Cells and Regenerative Medicine
Stem cell niche exit in
via orientation and segregation of daughter cells by a cryptic cell outside the niche
Kacy L Gordon et al.
A previously undetected dynamic cell structure orients the mitotic spindle of germ stem cells and grows over one daughter cell, thus helping to balance niche retention with niche exit.
Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons
Amrita Mukherjee et al.
The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.
MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation
Seiji Arai et al.
MARCH5 mediates a pathway driving MCL1 degradation in response to cellular stress, which sensitizes to BH3 mimetic drugs targeting BCLXL and provides a broadly effective therapeutic strategy for solid tumors.
Genetics and Genomics
Learning is enhanced by tailoring instruction to individual genetic differences
David G Mets, Michael S Brainard
Tailoring instructive experience to individual genetic biases improves vocal learning outcomes across genetic backgrounds in the Bengalese finch.
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