Local disinhibition provides a biologically plausible mechanism for flexible top-down control of network states that integrates normalized value coding, winner-take-all choice, and persistent activity in a single circuit of decision-making.
Paul Pfeiffer, Alexei V Egorov ... Susanne Schreiber
Independently gating ion channels typically act fast within milliseconds, but cooperative interactions within a cluster of channels allow for a memory of previous electrical activity for several seconds.
The interplay of recurrent excitation and short-term plasticity enables nonlinear transient amplification, an ideal mechanism for selective amplification, pattern completion, and pattern separation in recurrent neural networks.
Sebastien Wolf, Guillaume Le Goc ... Rémi Monasson
A data-driven model of the neural activity of a circuit essential to swimming orientation in zebrafish can be mathematically interpreted to unveil the dynamical mechanism leading to persistence in tail orientation.
Yucheng Xiao, Jonathan W Theile ... Theodore R Cummins
A-type fibroblast growth factor homologous factors generate resurgent currents in tetrodotoxin-resistant voltage-gated sodium channels, increase repetitive firing of sensory neurons, and provide a potentially important target for pain treatment strategies.
Direct estimation of the Hurst exponent shows that endosomes and lysosomes reside in regimes of persistent and anti-persistent motion with heavy-tailed residence time distributions and motion correlated with endocytic function.
Real-time visualization of Salmonella enterica and polarized macrophage interaction in the living host identifies an anti-inflammatory, pro-regenerative, and motionless macrophage subset as a survival niche during persistent infection.
Combined experimental and theoretical analysis identifies a molecular mechanism akin to working memory that enables single cells to perform complex navigation tasks in changing growth factor fields, beyond simple stimulus-response associations.
Carmen Lin, Venus N Sherathiya ... John F Disterhoft
Temporal associative learning enhances persistent firing in lateral entorhinal cortex (LEC) layer III neurons, while aging decreases persistent firing, leading to cognitive impairments.
