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Deficiencies of several DNA damage response genes can be predicted by their association with genome-wide mutation patterns.

The benefits of integrating cross-species systems genetics platforms to advance knowledge in the underlying mechanisms that drive cardiometabolic diseases have been investigated.

A proportion of glioblastoma with global hypo-methylation are enriched for an astrocytic signature and display increased invasion and altered immune landscape.

A mathematical model of osteoporosis explains why the sequence of osteoporosis medications matters for short-term and long-term treatment success.

Tailoring Boolean models to 488 prostate cancer patients and 8 cell lines data allows for the experimentally validated personalisation of drug treatments.

20 emerging issues in bioengineering that will have profound impacts on society have been identified.

Responses to anesthetics differ among individuals and fluctuate stochastically despite constant drug concentration, however, the amount of noise driving transitions between the responsive and the unresponsive state is conserved.

Loss of BAP1 function is associated with increased sensitivity to TRAIL and other death receptor agonists in malignant mesothelioma, where this is a frequent event, with immediate and actionable therapeutic implications.

A high-throughput functional validation system for large numbers of candidate disease genes enables in vivo functional testing of specific gene variants.

The Toxoplasma parasite requires an enzyme called ASP5 to cleave proteins for export into host cells.