157 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Pervasive transcription fine-tunes replication origin activity

    Tito Candelli et al.
    The pervasive transcription environment alters the efficiency of firing of replication origins, which are 'protected' by roadblock termination due to origin recognition complex (ORC) and pre-RC complexes.
    1. Cell Biology

    Transcription leads to pervasive replisome instability in bacteria

    Sarah M Mangiameli et al.
    Replication-transcription conflicts cause pervasive replisome instability.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

    Ana R Grosso et al.
    Transcription beyond annotated gene boundaries expands the diversity of the cancer transcriptome with overexpressed oncogenes and RNA chimeras.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Efficient termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance

    Dorine Jeanne Mari√ętte du Mee et al.
    RNA Polymerase II transcriptional termination of a nuclear long non-coding RNA is required to maintain the mitochondrial genome and hence promotes budding yeast growth.
    1. Cell Biology
    2. Genetics and Genomics

    Endogenous RNA interference is driven by copy number

    Cristina Cruz, Jonathan Houseley
    The ability to target transcripts from high-copy regions of the genome is an emergent property of a minimal RNA interference system.
    1. Chromosomes and Gene Expression

    Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

    Kevin Monahan et al.
    Biochemical and genetic experiments show that Ebf and Lhx2 cooperate to specify olfactory receptor enhancers, which cooperate to drive olfactory receptor expression.
    1. Developmental Biology

    DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

    Sebastian Canovas et al.
    Reproductive fluids help the correct establishment of some epigenetic marks and gene expression in preimplantation pig embryos.
    1. Plant Biology

    The Arabidopsis thaliana mobilome and its impact at the species level

    Leandro Quadrana et al.
    Population genomics in Arabidopsis thaliana uncovers an extensive repertoire of active transposable element families at the species level and reveals their importance as a source of rare alleles with large effects.
    1. Biochemistry and Chemical Biology

    The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs

    Mary K Thompson et al.
    Asc1/RACK1 promotes the translation of mRNAs associated with the translational closed loop complex, which have short open reading frames and encode proteins required for core metabolic processes.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

    James E Hughes Hallett et al.
    The key Target of Rapamycin Complex (TORC1) component Kog1 moves into bodies during glucose starvation to limit reactivation of the complex.

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