358 results found
    1. Cell Biology
    2. Evolutionary Biology

    Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

    Joshua G Dunn, Catherine K Foo ... Jonathan S Weissman
    Ribosomes translate through stop codons far more often than previously thought, yielding C-terminally extended proteins in a variety of eukaryotes.
    1. Cell Biology
    2. Genetics and Genomics

    Endogenous RNA interference is driven by copy number

    Cristina Cruz, Jonathan Houseley
    The ability to target transcripts from high-copy regions of the genome is an emergent property of a minimal RNA interference system.
    1. Cell Biology
    2. Developmental Biology

    Plasticity of both planar cell polarity and cell identity during the development of Drosophila

    Pedro Saavedra, Jean-Paul Vincent ... José Casal
    In the Drosophila larval epidermis both the cell identity and polarity of individual cells change as a result of cell rearrangements.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The life cycle of Drosophila orphan genes

    Nicola Palmieri, Carolin Kosiol, Christian Schlötterer
    The short lifetime of orphan genes is a major factor explaining the stability of gene number in Drosophila.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA

    Erich G Chapman, Stephanie L Moon ... Jeffrey S Kieft
    The Dengue virus contains discretely folded RNA structures that confer the ability to resist a powerful host cell enzyme and produce a disease-inducing noncoding RNA.
    1. Neuroscience

    Sex-specific processing of social cues in the medial amygdala

    Joseph F Bergan, Yoram Ben-Shaul, Catherine Dulac
    Male and female mice respond differently to the same pheromone signals, and the representation of these sensory stimuli by neurons in the medial amygdala correlates precisely with the differences in behavior.
    1. Chromosomes and Gene Expression

    Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells

    Nicolas Descostes, Martin Heidemann ... Jean-Christophe Andrau
    Genome-wide analysis reveals novel functions for a post-translational modification to the carboxy-terminal domain (CTD) of RNA Polymerase II in mammals.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast

    Sarah E Zanders, Michael T Eickbush ... Harmit Singh Malik
    Rapid acquisition of chromosome rearrangements, together with independently acting transmission distorter alleles on each chromosome, drive near complete sterility in fission yeast hybrids.
    1. Cell Biology
    2. Developmental Biology

    Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

    Pavan Kumar P, Uchenna Emechebe ... Anne M Moon
    A novel master regulatory mechanism of cell proliferation and senscence employs the lncRNA UCA1 and a CAPERα/TBX3 corepressor.
    1. Genetics and Genomics

    High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species

    Molly Schumer, Rongfeng Cui ... Peter Andolfatto
    Genetic incompatibilities are common and widely distributed throughout the genomes of swordtail fish, and prevent the regions of the genome around them from being exchanged between different species.

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