Synthetic single domain antibody libraries and a binder selection cascade encompassing ribosome and phage display enable the selection of conformation-specific binders against previously intractable membrane proteins within three weeks.
Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.
Direct cortical recordings in humans link the spectral structure of local field potentials to inhibition/disinhibition mechanisms coordinating sensorimotor neuronal populations during movement imagery.
Nanobodies are developed that target neuronal proteins with restricted subcellular distributions and used as intrabodies to deliver cargo to specific sites within neurons and nanoscale immunolabels for improved imaging resolution.