65 results found
    1. Evolutionary Biology

    Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

    Claudia Igler et al.
    The number and effects of mutations leading to full drug resistance crucially determine treatment failure probability and should be used to inform antimicrobial treatment strategies with regard to avoidance of resistance emergence.
    1. Microbiology and Infectious Disease

    The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

    Stephen Patterson et al.
    Biological and pharmacokinetic studies indicate that the anti-tubercular drug, delamanid, could be repurposed for the treatment of visceral leishmaniasis.
    1. Cancer Biology

    The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

    James D Joseph et al.
    GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.
    1. Cell Biology

    Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

    Scott J Dixon et al.
    Erastin and sorafenib inhibit system xc- and induce ER stress, suggesting these may be useful tools for probing the functions of system xc- and its role in inducing ER stress and ferroptosis.
    1. Evolutionary Biology

    An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

    Valerie J Morley et al.
    Cholestyramine, an FDA-approved bile acid sequestrant, can be repurposed to inactivate the antibiotic daptomycin in the gut, which prevents the emergence of transmissible antibiotic resistance in gastrointestinal Enterococcus faecium populations.
    1. Medicine

    Concentration-dependent mortality of chloroquine in overdose

    James A Watson et al.
    Most chloroquine regimens trialled for the treatment of COVID19 will not result in life-threatening cardiovascular toxicity.
    1. Medicine

    Science Forum: Improving preclinical studies through replications

    Natascha Ingrid Drude et al.
    Increasing validity should be a priority when deciding which preclinical experiments to replicate and when performing replications.
    1. Microbiology and Infectious Disease

    Bidirectional interactions between indomethacin and the murine intestinal microbiota

    Xue Liang et al.
    Indomethacin, a nonsteroidal anti-inflammatory drug, alters the composition of the intestinal microbiota, and the intestinal microbiota affect the pharmacokinetics of indomethacin.
    1. Computational and Systems Biology

    Antibiotic-induced population fluctuations and stochastic clearance of bacteria

    Jessica Coates et al.
    The extinction of bacterial populations by antibiotics is stochastic and can be predicted only probabilistically, not deterministically.
    1. Neuroscience

    Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

    Sthitapranjya Pati et al.
    Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.

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