5 results found
    1. Epidemiology and Global Health
    2. Medicine

    Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers

    Sasithon Pukrittayakamee, Podjanee Jittamala ... Nicholas J White
    A full radical curative dose of primaquine can be given to fully glucose-6-phosphate dehydrogenase-deficient males safely using an ascending dose regimen.
    1. Medicine

    Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)

    William HK Schilling, Podjanee Jittamala ... Nicholas J White
    Pharmacometric evaluation of viral clearance rates based on frequent oropharyngeal sampling is a highly efficient and well-tolerated method of assessing and comparing SARS-CoV-2 antiviral therapeutics in vivo.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis

    James A Watson, Robert J Commons ... Nicholas J White
    The currently recommended adult dose of tafenoquine is insufficient for radical cure in all adults.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    James A Watson, Carolyne M Ndila ... Nicholas J White
    Complete blood count data can increase the accuracy of the diagnosis of severe malaria in children in high transmission settings.
    1. Medicine

    Concentration-dependent mortality of chloroquine in overdose

    James A Watson, Joel Tarning ... Nicholas J White
    Most chloroquine regimens trialled for the treatment of COVID19 will not result in life-threatening cardiovascular toxicity.

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