6,389 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of opening and closing of the bacterial replicative helicase

    Jillian Chase et al.
    Analysis of the Escherichia coli DnaB helicase•bacteriophage λ helicase loader (λP) complex provides insights into helicase opening, delivery to the origin and ssDNA entry, and closing in preparation for translocation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Ecology
    2. Evolutionary Biology

    CRISPR-based herd immunity can limit phage epidemics in bacterial populations

    Pavel Payne et al.
    Bacteria can exhibit herd immunity protection against phages, which may play a significant role in their ecology and evolution.
    1. Microbiology and Infectious Disease

    Dominant Vibrio cholerae phage exhibits lysis inhibition sensitive to disruption by a defensive phage satellite

    Stephanie G Hays, Kimberley D Seed
    Genetic and molecular analyses identify and characterize an evolutionary battle over lysis timing wherein a bacteriophage delays lysis through lysis inhibition while a defensive phage satellite accelerates lysis.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The mobility of packaged phage genome controls ejection dynamics

    Alex Evilevitch
    Temperature and ionic conditions control the mechanical properties of virally encapsidated DNA and act as a switch between synchronized and desynchronized genome ejection dynamics in a phage population.
    1. Developmental Biology
    2. Plant Biology

    Sugar promotes vegetative phase change in Arabidopsis thaliana by repressing the expression of MIR156A and MIR156C

    Li Yang et al.
    Sugar levels in leaves act as a signal for plants to switch from their juvenile to their adult form by regulating the expression of two genes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

    Xiaohu Guo et al.
    The first structure of a bacteriophage-encoded S-adenosyl methionine degrading enzyme was solved and demonstrated to catalyze a unimolecular lyase reaction occurring at the domain interface of a trimeric structure.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Phage integration alters the respiratory strategy of its host

    Jeffrey N Carey et al.
    A temperate bacteriophage reprograms the oxygen response of a bacterial signaling system by replacing a host-encoded promoter with a phage-encoded promoter.
    1. Microbiology and Infectious Disease

    Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

    Kevin J Forsberg et al.
    A high-throughput, activity-based selection identifies many phage-derived inhibitors of Cas9 from human fecal and oral metagenomes, with at least one inhibitor acting via a novel mechanism.
    1. Physics of Living Systems

    Charge-driven condensation of RNA and proteins suggests broad role of phase separation in cytoplasmic environments

    Bercem Dutagaci et al.
    Charge complementarity between RNA and proteins may be a universal principle for phase separation in biology without requiring disorder or specific multivalent interactions.

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