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Direct- and indirect pathway neurons of the posterior striatum display divergent in vivo and ex vivo plasticity after fear learning, and differentially modulate defensive behaviors displayed in the presence, and absence of threat-predicting sensory cues.

Exosomes secreted from pancreatic cancer cells can function as a classic initiator in the multi-step cellular transformation process.

fMRI evidence for distinct hierarchical alterations in intrinsic neural timescales for different positive symptoms of schizophrenia support hierarchical perceptual-inference models of psychosis and suggest local increases in excitation-inhibition ratio.

An experimental animal model provides further insights into the host and viral mechanisms underlying airborne transmission of SARS-CoV-2.

Models that generate tandem alignments of cell polarities are more readily compatible with the formation of PIN1 polarity patterns in plant leaf buds than the most widely accepted “up-the-gradient” model.

Network topology and gene expression patterns in small cell lung cancer reveal two mutually opposing teams of regulators that enable multistability and consequent non-genetic heterogeneity, a clinically unsolved challenge.

Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.

Curvature-preferring neurons in monkey V4 cluster into 0.5-mm patches, which highlights the importance of curvature detection in visual object recognition and the key functional role of V4 in this process.

The nanoscopic landscape of the membrane has a direct impact on the spatiotemporal, and likely also the signaling, dynamics of Ras proteins.

Computational modeling revealed that balanced assemblies of excitatory and inhibitory neurons shape representational manifolds in olfactory cortex-like recurrent networks, resulting in joint maps of sensory and semantic information.