3,004 results found
    1. Neuroscience

    Intrinsic mechanical sensitivity of mammalian auditory neurons as a contributor to sound-driven neural activity

    Maria C Perez-Flores, Eric Verschooten ... Ebenezer N Yamoah
    In vitro and in vivo physiological analyses reveal that mammalian auditory neuron intrinsic mechanical sensitivity contributes to sound-evoked activity and explains other previously unexplained auditory neuron features.
    1. Medicine
    2. Microbiology and Infectious Disease

    Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis

    Tyler Wagner, FNU Shweta ... Venky Soundararajan
    Applying deep learning technology for the large-scale curation of symptoms from unstructured EHR clinical notes accurately predicts the differential signals of COVID-19 diagnosis over the week preceding typical PCR testing.
    1. Ecology

    Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

    Yang Ruan, Ning Ling ... Zhibiao Nan
    Warming and altered precipitation reduce the growth rates of alpine soil bacteria by 40-90%, and the growth of ~70% taxa is influenced by antagonistic interactions between factors.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Core genes can have higher recombination rates than accessory genes within global microbial populations

    Asher Preska Steinberg, Mingzhi Lin, Edo Kussell
    Homologous recombination rates tend to be highest in the most conserved parts of bacterial genomes.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank

    Ardalan Naseri, Degui Zhi, Shaojie Zhang
    ROH-DICE is an efficient method for detecting ROH clusters in biobank data, enabling the study of population history of large cohorts, and providing a new genome-wide association analysis approach for finding disease-causing loci with multi-marker recessive effects.
    1. Evolutionary Biology

    The Jurassic rise of squamates as supported by lepidosaur disparity and evolutionary rates

    Arnau Bolet, Thomas L Stubbs ... Michael J Benton
    Evidence for a largely unexplored radiation of squamates (lizards, snakes, and amphisbaenians) in the Middle to Late Jurassic is revealed by analyses of morphospace expansion, disparity, and evolutionary rates.
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative modelling approach to zebrafish pigment pattern formation

    Jennifer P Owen, Robert N Kelsh, Christian A Yates
    A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
    1. Cell Biology
    2. Physics of Living Systems

    Bridging the gap between single-cell migration and collective dynamics

    Florian Thüroff, Andriy Goychuk ... Erwin Frey
    A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genetic basis of Arabidopsis thaliana responses to infection by naïve and adapted isolates of turnip mosaic virus

    Anamarija Butkovic, Thomas James Ellis ... Santiago F Elena
    Arabidopsis lines were screened for resistance to TuMV, identifying a region on chromosome 2 linked to necrosis that includes an antiviral gene.
    1. Neuroscience
    2. Computational and Systems Biology

    The individuality of shape asymmetries of the human cerebral cortex

    Yu-Chi Chen, Aurina Arnatkevičiūtė ... Kevin M Aquino
    Asymmetries between the shape of the left and right human cortex are highly unique to individuals, akin to a neuroanatomical fingerprint, related to cognitive function, and primarily driven by person-specific environmental influences.

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