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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal

    Johann Mignolet, Guillaume Cerckel ... Pascal Hols
    A new cell–cell communication system in Streptococcus salivarius, a human gut commensal, discriminates between close signaling molecules to specifically produce bacteriocin-based antimicrobials and disconnects it from foreign DNA acquisition.
    1. Evolutionary Biology
    2. Neuroscience

    A novel lineage of candidate pheromone receptors for sex communication in moths

    Lucie Bastin-Héline, Arthur de Fouchier ... Nicolas Montagné
    In moths, male receptors tuned to type I female pheromones may not have a monophyletic origin.
    1. Neuroscience

    Two single-point mutations shift the ligand selectivity of a pheromone receptor between two closely related moth species

    Ke Yang, Ling-Qiao Huang ... Chen-Zhu Wang
    Differing from its ortholog in Helicoverpa armigera, pheromone receptor HassOr14b is tuned to the major sex pheromone component in H. assulta, and two amino acids in the intracellular domain determine their ligand selectivity.
    1. Neuroscience

    Excitation and inhibition onto central courtship neurons biases Drosophila mate choice

    Benjamin R Kallman, Heesoo Kim, Kristin Scott
    Pheromones activate excitatory and inhibitory pathways that are integrated to guide mating decisions in Drosophila melanogaster.
    1. Evolutionary Biology

    Convergent evolution of small molecule pheromones in Pristionchus nematodes

    Chuanfu Dong, Cameron J Weadick ... Ralf J Sommer
    Unexpected structural diversity of nematode small molecules, as revealed by high-resolution phylogenetic analysis, suggests recurrent biochemical innovation, a pattern that is probably typical across animals.
    1. Biochemistry and Chemical Biology

    Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans

    Yue Zhou, Yuting Wang ... Rebecca A Butcher
    In response to starvation, C. elegans converts a favorable pheromone that induces aggregation to an unfavorable one that induces a stress-resistant larval stage, thereby altering its chemical message without having to synthesize new pheromones de novo.
    1. Evolutionary Biology

    Expansion of the fatty acyl reductase gene family shaped pheromone communication in Hymenoptera

    Michal Tupec, Aleš Buček ... Iva Pichová
    A fatty acyl reductase gene family expansion in the Hymenoptera crown group led to recruitment of novel pheromone-biosynthetic enzymes and is linked to evolution of pheromone marking behavior.
    1. Neuroscience

    Alcohol potentiates a pheromone signal in flies

    Annie Park, Tracy Tran ... Nigel S Atkinson
    For Drosophila melanogaster, the scent of alcohol—normally associated with preferred egg-laying sites—potentiates a male pheromone signal, thereby increasing the aggressive competition between males for the reproductive resource.
    1. Developmental Biology
    2. Genetics and Genomics

    miR-124 controls male reproductive success in Drosophila

    Ruifen Weng, Jacqueline SR Chin ... Stephen M Cohen
    A small RNA molecule called miR-124 controls pheromone production and sexual behaviour in Drosophila by regulating sex-specific gene expression in males.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Sex-specific triacylglycerides are widely conserved in Drosophila and mediate mating behavior

    Jacqueline SR Chin, Shane R Ellis ... Joanne Y Yew
    Triacylglycerides found in the males of 11 species of Drosophila form a largely overlooked, novel, sex-specific class of pheromones that act to suppress courtship behaviour.