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    1. Stem Cells and Regenerative Medicine

    Philosophy of Biology: Towards a classification of stem cells

    Lucie Laplane, Eric Solary
    The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.

  2. Philosophy of Biology: Understanding regeneration at different scales

    Kate MacCord, Jane Maienschein
    To understand how regeneration works across the different scales of living systems, we first need to identify the essential components underlying this process.
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.
    1. Cancer Biology

    Replication of null results: Absence of evidence or evidence of absence?

    Samuel Pawel, Rachel Heyard ... Leonhard Held
    Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.

  5. Helping the neighbours: an interview with Meredith Schuman

    Meredith Schuman was born in Minneapolis, Minnesota, USA, and is currently leading a junior research group at the German Center for Integrative Biodiversity Research (iDiv), where she investigates the ecological roles of genes in populations of the wild tobacco plant Nicotiana attenuata. She hopes to find a tenure-track position in molecular chemical ecology when funding for her current position ends in 2017. Her hobbies include reading, writing, running, hiking, bodyweight training and travel, and she loves teaching.
    1. Structural Biology and Molecular Biophysics

    Science Forum: Building a community to engineer synthetic cells and organelles from the bottom-up

    Oskar Staufer, Jacqueline A De Lora ... Gabriel P López
    The creation of synthetic cells and organelles will open doors to new collaborative and funding opportunities.

  7. Point of View: How should novelty be valued in science?

    Barak A Cohen
    An over-emphasis on novelty is having detrimental effects on science.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-selected mutations converging on a global regulator drive an adaptive leap towards symbiosis in bacteria

    M Sabrina Pankey, Randi L Foxall ... Cheryl A Whistler
    Selective forces imposed by the squid animal host drive rapid adaptation of non-native Vibrio fischeri bacteria through convergent mutations of large effect, unmasking preexisting coordinated regulation of symbiosis.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Point of View: Biological causal links on physiological and evolutionary time scales

    Amit Karmon, Yitzhak Pilpel
    Increasing awareness that many causal links in biology might be bi-directional could overcome biases and improve scientific reasoning.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Science Forum: A low-cost, open-source evolutionary bioreactor and its educational use

    Vishhvaan Gopalakrishnan, Dena Crozier ... Jacob G Scott
    The EVolutionary biorEactor (EVE) can be built for less than $200, and can be used to evaluate microbial population dynamics in the lab and to teach evolution in high schools.
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