130 results found
    1. Structural Biology and Molecular Biophysics

    An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein

    Sneha Menon, Subinoy Adhikari, Jagannath Mondal
    Interaction of small molecule expands the conformational ensemble of alpha synuclein.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    DGRPool, a web tool leveraging harmonized Drosophila Genetic Reference Panel phenotyping data for the study of complex traits

    Vincent Gardeux, Roel PJ Bevers ... Bart Deplancke
    The DGRPool web tool aggregates phenotyping data from the Drosophila Genetic Reference Panel, streamlining genetic association studies and offering new insights into genetic and phenotypic variation in complex traits.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

    Amanda C Perofsky, John Huddleston ... Cécile Viboud
    Antigenic drift in influenza’s major surface proteins, hemagglutinin and neuraminidase, contributes to variability in epidemic magnitude across seasons but is less influential than subtype interference in shaping annual outbreaks.
    1. Physics of Living Systems

    Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women

    Alex James, Franca Buelow ... Ann Brower
    There is a systemic bias in research evaluation, i.e., disciplines with a higher proportion of women have lower evaluations and funding success for all researchers, regardless of gender.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Neuroscience

    A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings

    Proloy Das, Mingjian He, Patrick L Purdon
    Oscillation component analysis enables cognitive neuroscientists to summarize millisecond-precision high-dimensional neurophysiological recordings into a smaller set of oscillatory components through biophysically inspired generative modeling of neural oscillations.
    1. Physics of Living Systems

    Gendered hiring and attrition on the path to parity for academic faculty

    Nicholas LaBerge, Kenneth Hunter Wapman ... Daniel B Larremore
    Achieving gender parity among U.S. tenured and tenure-track faculty will require changes to hiring, which has substantially greater impacts on faculty gender representation than gendered differences in attrition rates.
    1. Developmental Biology

    Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

    Siyuan Cheng, Ivan Fan Xia ... Stefania Nicoli
    Flow hemodynamic activation of endothelial klf2a is a mechanism regulating initial vascular smooth muscle cell differentiation on circle of Willis arteries.
    1. Structural Biology and Molecular Biophysics

    PPIscreenML: Structure-based screening for protein-protein interactions using AlphaFold

    Victoria Mischley, Johannes Maier ... John Karanicolas
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Widespread Horizontal Gene Transfer Among Animal Viruses

    Christopher B. Buck, Nicole Welch ... Gabriel J. Starrett
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Computational and Systems Biology

    Statistical and computational methods for integrating microbiome, host genomics, and metabolomics data

    Rebecca A Deek, Siyuan Ma ... Hongzhe Li
    Advanced statistical and computational methods are reviewed and compared for integrating microbiome, host genomics, and metabolomics data, together with future research directions.

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