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    1. Stem Cells and Regenerative Medicine

    Philosophy of Biology: Towards a classification of stem cells

    Lucie Laplane, Eric Solary
    The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.
  1. Philosophy of Biology: Philosophical bias is the one bias that science cannot avoid

    Fredrik Andersen, Rani Lill Anjum, Elena Rocca
    Scientists should be aware of the non-empirical assumptions that influence all kinds of research.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence

    Diane Marie Keeling, Patricia Garza ... Anne-Ruxandra Carvunis
    A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
  2. Point of View: Science, art, society and Klimt’s University of Vienna paintings

    Alberto E Pereda
    A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.
    1. Cancer Biology

    Replication of null results: Absence of evidence or evidence of absence?

    Samuel Pawel, Rachel Heyard ... Leonhard Held
    Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Radiocarbon and genomic evidence for the survival of Equus Sussemionus until the late Holocene

    Dawei Cai, Siqi Zhu ... Yu Jiang
    The first nuclear genomes of the Equus (Sussemionus) ovodovi enable us to reconstruct the speciation and extinction trajectory of this lineage.
    1. Physics of Living Systems

    Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women

    Alex James, Franca Buelow ... Ann Brower
    There is a systemic bias in research evaluation, i.e., disciplines with a higher proportion of women have lower evaluations and funding success for all researchers, regardless of gender.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Neuroscience

    Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia

    Xiaohui Yan, Ke Jiang ... Fan Cao
    Convergent structural and functional brain deficits associated with dyslexia were found in left superior temporal gyrus across languages, however, language-specific deficits were also identified.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Point of View: Looking back and looking forward at Janelia

    Gerald M Rubin, Erin K O'Shea
    The Janelia Research Campus opened its doors 12 years ago: we describe the philosophy underpinning Janelia, the lessons learned, and plans for the future.
    1. Immunology and Inflammation

    Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

    Ali Reza Ahmadi, Guang Song ... Zhaoli Sun
    Massive IgG and IgA antibody deposition in severe alcoholic hepatitis livers, targeting unique human proteins and exhibiting hepatocyte killing potential, suggests a role for cross-reactive anti-bacterial antibodies in severe alcoholic hepatitis pathogenesis.