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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

    Johanne Le Coq et al.
    The SHIP2 inositol phosphatase is an important upstream regulator of the Akt signaling pathway, which requires a catalytic core formed by the phosphatase domain tightly packed to a C2 domain for its function.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

    Niels Bradshaw et al.
    Structures of active and inactive conformations of a PP2C family phosphatase reveal a conserved switch that controls enzymatic activity and point to an unexpected relationship between phosphatases and proteasomal proteases.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)

    Joshua J Filter et al.
    Unfair competition, in which a phosphatase and a phosphoprotein inhibitor/substrate mutually sequester each other from competing substrates and enzymes, is a conserved mechanism for the control of PPP family phosphatases.
    1. Structural Biology and Molecular Biophysics
    2. Cancer Biology

    The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism

    Ganesan Senthil Kumar et al.
    Building on previous work (Booth et al, 2014), we show how two mitotic phosphatases are formed, how they are regulated by opposing kinases during the cell cycle and reveal a novel opportunity for the development of cancer therapeutics.
    1. Biochemistry and Chemical Biology

    PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

    Kerryn Berndsen et al.
    PPM1H protein phosphatase dephosphorylates Rab proteins modulating LRRK2 signalling.
    1. Neuroscience

    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

    Adelaida M Celaya et al.
    Mitogen-activated protein kinase phosphatase 1 (DUSP1) deficiency causes early redox imbalance and increased inflammatory response in the cochlea, leading to cell loss and progressive neurosensory hearing loss.
    1. Plant Biology

    LPCAT1 controls phosphate homeostasis in a zinc-dependent manner

    Mushtak Kisko et al.
    Phosphate accumulation in zinc-deficient Arabidobsis shoots is regulated by a pathway involving the transcription factor bZIP23, the phospholipid-remodelling enzyme LPCAT1 and the transporter PHT1;1.
    1. Developmental Biology

    Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase

    Frédéric Bonnet et al.
    The cell cycle phosphatase CDC25B controls cell cycle progression and neurogenesis through independent pathways.
    1. Microbiology and infectious disease

    Asymmetric division triggers cell-specific gene expression through coupled capture and stabilization of a phosphatase

    Niels Bradshaw, Richard Losick
    Asymmetric cell division is linked to cell-specific transcription by handoff of a key developmental regulator from the cytokinetic machinery to the adjacent cell pole where it oligomerizes to become stabilized and activated.
    1. Plant Biology

    A chloroplast retrograde signal, 3’-phosphoadenosine 5’-phosphate, acts as a secondary messenger in abscisic acid signaling in stomatal closure and germination

    Wannarat Pornsiriwong et al.
    Molecular signals from chloroplasts can synergistically interact with the plant hormone, abscisic acid (ABA), to regulate non-canonical signaling pathways mediating fundamental cellular processes including stomatal closure, seed dormancy and germination.