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    1. Cell Biology

    Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

    Craig A Nash et al.
    β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
    1. Neuroscience

    α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

    Reeba Susan Jacob et al.
    Plasma membrane clusters of the Parkinson's disease protein α-synuclein colocalize with negatively charged phospholipids involved in endocytosis and exocytosis.
    1. Cell Biology
    2. Computational and Systems Biology

    Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

    Alison L Kearney et al.
    Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.
    1. Plant Biology

    Structural basis for plant plasma membrane protein dynamics and organization into functional nanodomains

    Julien Gronnier et al.
    Unprecedented resolution of the molecular mechanisms of plant membrane protein anchoring involving phospholipids and sterols reveals the control of spatio-temporal segregation into plasma membrane nanodomains.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium

    Ángel Pérez-Lara et al.
    Two acidic membrane lipids increase synaptotagmin-1 dwell time and penetration into the membrane, reducing the membrane dissociation of synaptotagmin-1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes

    Fangfei Qu et al.
    Ankyrin-B – through interactions with PI3P lipids, dynactin and RabGAP1L – functions as a critical node in the protein circuitry underlying polarized recycling of α5β1-integrin to enable haptotaxis along fibronectin gradients.
    1. Microbiology and Infectious Disease

    Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes

    Shuxin Liu et al.
    A novel bacterial deubiquitinase with multiple chain types specificity regulates the association of ubiquitinated proteins on the phagosome of Legionella pneumophila.
    1. Developmental Biology
    2. Genetics and Genomics

    Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

    Jason W Millington et al.
    The ability to adjust body size in response to diet is greater in Drosophila females than males because of a sex difference in the nutrient-dependent regulation of the insulin pathway.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

    Manoj K Rathinaswamy et al.
    The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.
    1. Cell Biology
    2. Developmental Biology

    Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

    Eric T Hall et al.
    Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.