310 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

    Kuan-Yi Lu et al.
    Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.
    1. Cell Biology
    2. Neuroscience

    Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

    Alexander M Walter et al.
    Increasing PI(4,5)P2 on a sub-second timescale using a novel, membrane-permeant UV activatable PI(4,5)P2 molecule augments exocytosis which requires the PI(4,5)P2 interacting exocytotic proteins Munc13-2 and synaptotagmin-1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

    Liang Ge et al.
    Building on previous work (Ge et al., 2013), it is shown that the ER-Golgi intermediate compartment is a platform for the production of COPII vesicles as precursor membranes for the lipidation of LC3, which is an essential step in autophagosome biogenesis.
    1. Developmental Biology
    2. Neuroscience

    Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II

    Chwee Tat Koe et al.
    Vibrator and PI4KIIIα that stimulate the synthesis of PI(4)P anchor non-muscle myosin II RLC (Sqh) to the plasma membrane and conversely Sqh associates with PI(4)P and facilitates its membrane localization during asymmetric division of neuroblasts.
    1. Neuroscience

    α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

    Reeba Susan Jacob et al.
    Plasma membrane clusters of the Parkinson's disease protein α-synuclein colocalize with negatively charged phospholipids involved in endocytosis and exocytosis.
    1. Structural Biology and Molecular Biophysics

    A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

    Danish Khan et al.
    A new class of fungal hemoproteins is described that emphasizes the versatility of the Sec14-fold for translating binding of chemically distinct ligands to control of diverse sets of cellular activities.
    1. Structural Biology and Molecular Biophysics

    Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

    Sulochanadevi Baskaran et al.
    The first three-dimensional structure of the PI3KC3 complex I, which is involved in autophagy, provides a framework for understanding the allosteric regulation of lipid kinase activity.
    1. Cell Biology
    2. Developmental Biology

    The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling

    Bo Gong et al.
    Sec14l3/SEC14L2 respond to upstream Wnt/Frizzled/Dvl stimulation to recruit and activate phospholipase Cδ4a (Plcδ4a) to further initiate calcium release.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes

    Rashmi Voleti et al.
    Ca2+-free synaptotagmin-1 binds to neuronal SNARE complexes anchored on nanodiscs, and Ca2+ releases this interaction to induce tight, specific binding to PIP2-containing membranes.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium

    Ángel Pérez-Lara et al.
    Two acidic membrane lipids increase synaptotagmin-1 dwell time and penetration into the membrane, reducing the membrane dissociation of synaptotagmin-1.

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