311 results found
    1. Cell Biology

    A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling

    Sho W Suzuki et al.
    PX-BAR Mvp1 and dynamin-like GTPase Vps1 drive retromer-independent endosomal recycling.
    1. Cell Biology

    Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

    Lisa M Strong et al.
    The crystal structure of human WIPI2 bound to the ATG16L1 WIPI2-interacting region, combined with in vitro reconstitution and cellular autophagy assays, shows how the LC3 lipidation machinery is recruited in autophagy initiation.
    1. Immunology and Inflammation

    ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

    Miaomiao Tian et al.
    Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.
    1. Biochemistry and Chemical Biology

    Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

    Maxime Louet et al.
    A combination of state-of-the-art biochemical, biophysical, and computational methods revealed that water molecules play a central role in signal propagation through G protein-coupled receptors.
    1. Cell Biology
    2. Neuroscience

    TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

    Ki Bum Um et al.
    The non-selective Na+ leak channel (NALCN) and the transient receptor potential 3 channel (TRPC3) cooperate in driving pacemaking in substantia nigra dopaminergic neurons.
    1. Medicine

    7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

    Fan Xue et al.
    In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.
    1. Cell Biology
    2. Computational and Systems Biology

    Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

    Alison L Kearney et al.
    Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.
    1. Physics of Living Systems

    Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53

    Kaushik Inamdar et al.
    The formation of HIV-1 particles requires a bending of the membrane that cannot be achieved by the Gag protein alone and thus there is need for the I-BAR protein IRSp53 to aid in the formation of HIV-1 buds.
    1. Cancer Biology
    2. Cell Biology

    A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis

    Jesusa Capera et al.
    The association of caveolin with the potassium channel Kv1.3 fine-tunes cell survival and apoptosis.
    1. Cancer Biology
    2. Cell Biology

    Science Forum: Nanoscape, a data-driven 3D real-time interactive virtual cell environment

    Shereen R Kadir et al.
    Computer visualization techniques developed for video games can be repurposed to enable viewers to explore cells and their environment in three dimensions.

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