126 results found
    1. Cell Biology
    2. Neuroscience

    FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

    Tae-In Kam et al.
    By binding to Fc gamma receptor IIb, amyloid beta induces a series of phosphorylation events that mediate the damaging effects of hyperphosphorylated tau proteins in Alzheimer's disease.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

    Osama F Harraz et al.
    TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

    Anastasiia Stratiievska et al.
    A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli.
    1. Structural Biology and Molecular Biophysics

    Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

    Ivan KH Poon et al.
    A novel innate defense mechanism of cell lysis involves the coordinated oligomerization of a defensin by interaction with the membrane lipid, phosphatidylinositol 4,5-bisphosphate.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane

    Pascal Weber et al.
    A step of contact establishment preceding stable membrane attachment by palmitoylation is identified.
    1. Cell Biology

    Dynein-mediated transport and membrane trafficking control PAR3 polarised distribution

    Julie Jouette et al.
    In Drosophila oocytes, the exclusion of the scaffold protein PAR3 from the posterior cortex depends on PAR1 and endocytosis, while its anterior localisation requires microtubules and recycling endosomes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

    Julia P Steringer et al.
    The first reconstitution of an unconventional secretory mechanism uncovered the molecular mechanism by which Fibroblast Growth Factor 2 is secreted from mammalian cells.
    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of phospholipid activation of the human TPC2 channel

    Ji She et al.
    Cryo-EM structures of human TPC2 channel in the ligand-bound and apo states reveal the structural mechanism of PI(3,5)P2 lipid regulated gating of TPC2.
    1. Structural Biology and Molecular Biophysics

    The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

    Akira Kawanabe et al.
    Electrophysiological and fluorometric studies of Ci-VSP expressed in Xenopus oocyte revealed two states of the enzyme region with distinct enzyme activity and distinct coupling to the voltage sensor.
    1. Cell Biology

    The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

    Danielle DiTirro et al.
    A Tubby protein regulates ciliary membrane morphology and phosphoinositide composition in a context-dependent manner.

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