Two acidic membrane lipids increase synaptotagmin-1 dwell time and penetration into the membrane, reducing the membrane dissociation of synaptotagmin-1.
TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.
A new class of fungal hemoproteins is described that emphasizes the versatility of the Sec14-fold for translating binding of chemically distinct ligands to control of diverse sets of cellular activities.
The first reconstitution of an unconventional secretory mechanism uncovered the molecular mechanism by which Fibroblast Growth Factor 2 is secreted from mammalian cells.
In addition to its role in regulating proliferation and cell death, the PTEN tumor suppressor regulates epithelial morphogenesis through the PDK1 kinase.
The interplay between the Flower Ca2+ channel and PI(4,5)P2 spatiotemporally couples synaptic vesicle exocytosis to activity-dependent bulk endocytosis and synaptic vesicle reformation from bulk endosomes.
A newly identified component in the architecture of the axon/myelin-unit – the septin/anillin scaffold – maintains the structure of myelin in the central nervous system, thereby preventing myelin outfoldings.
In Drosophila oocytes, the exclusion of the scaffold protein PAR3 from the posterior cortex depends on PAR1 and endocytosis, while its anterior localisation requires microtubules and recycling endosomes.
