661 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Novel transgenic pigs with enhanced growth and reduced environmental impact

    Xianwei Zhang, Zicong Li ... Zhenfang Wu
    Transgenic expression of glucanase, xylanase and phytase in pigs enhances growth performance and reduces nitrogen/phosphorus emission, and offers a very valuable biological strategy for sustainable resource utilization and environmental protection in the pork industry.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Pollution: Transgenic pigs to the rescue

    Björn Petersen
    Genetically engineered pigs that digest their food better could help to reduce phosphorus and nitrogen pollution.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

    Felipe Trajtenberg, Juan A Imelio ... Alejandro Buschiazzo
    The molecular mechanism of switching between phosphotransferase- and phosphatase-competent states in histidine-kinases has been uncovered, through direct crystallographic observation of bona fide complexes between a histidine-kinase and its response regulator from Bacillus subtilise.
    1. Ecology

    The lost world of Cuatro Ciénegas Basin, a relictual bacterial niche in a desert oasis

    Valeria Souza, Alejandra Moreno-Letelier ... Luis Enrique Eguiarte
    At Cuatro Ciénegas, the ancestral niche conditions of the ancient shores of Laurentia persisted along with its microbial communities that have been coevolving for a very long time.
    1. Cell Biology

    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

    Herschel S Dhekne, Francesca Tonelli ... Suzanne R Pfeffer
    Activating mutations in the leucine-rich repeat kinase 2 cause Parkinson’s disease, and an unbiased genome-wide screen revealed an unexpected, specific role for Rab12 in activating this kinase directly for Rab GTPase phosphorylation.
    1. Ecology
    2. Plant Biology

    A dynamic rhizosphere interplay between tree roots and soil bacteria under drought stress

    Yaara Oppenheimer-Shaanan, Gilad Jakoby ... Tamir Klein
    Increased root exudation rate under combined drought and bacterial inoculation and bacterial growth stimulation by specific exudation metabolites support the idea of root recruitment of beneficial bacteria, especially under water stress.
    1. Cell Biology

    3D visualization of mitochondrial solid-phase calcium stores in whole cells

    Sharon Grayer Wolf, Yael Mutsafi ... Deborah Fass
    Mammalian mitochondria in living cells store calcium phosphate in solid form.
    1. Medicine

    Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model

    Jeong-Oh Shin, Jong-Bin Lee ... Jin-Woo Kim
    rhPTH(1-34) and dimeric R25CPTH(1-34) significantly promoted bone regeneration and titanium implant osseointegration in an osteoporotic beagle model.
    1. Biochemistry and Chemical Biology

    Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site

    Fanny Sunden, Ariana Peck ... Daniel Herschlag
    Conventional studies have focused on enzymatic residues directly involved in catalysis; dissecting a potential interaction network within which these ‘catalytic residues’ are embedded provides insights fundamental to enzyme function, evolution, and engineering.
    1. Ecology

    Genomic adaptations in information processing underpin trophic strategy in a whole-ecosystem nutrient enrichment experiment

    Jordan G Okie, Amisha T Poret-Peterson ... James J Elser
    Trait-based metagenomic analysis of an ecosystem fertilization experiment shows that genomic traits that affect the costs and rates of biochemical information-processing mediate community assembly.

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