Mechanistic insight into the chaperone-like activity of NMNAT to phosphorylated Tau reveals a connection between NAD⁺metabolism and Tau homeostasis.

Phosphorylated tau was related to a loss of structural stability in medial temporal lobe connectivity, and this loss of stability moderated the relationship between phosphorylated tau accumulation and memory decline.

A new study has identified the proteins that adapt COPII vesicles to the needs of starving cells.

Extremely low numbers of active epidermal growth factor receptors are sufficient to drive tumor growth.

Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.

Ser57 phosphorylation of ubiquitin protects the cell during proteotoxic stress.

Redox modification of STING represents a novel target for interferon regulation and control of herpesvirus replication.

Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.

Metabolic cues enlist ubiquitin ligase adaptors for the selective control of cellular nutrient acquisition strategies.