243 results found
    1. Cell Biology

    The number of cytokinesis nodes in mitotic fission yeast scales with cell size

    Wasim A Sayyad, Thomas D Pollard
    Fission yeasts cells have about 190 cytokinesis nodes in a broad band at the equator which scales with cell size and most but not all nodes condense into the contractile ring.
    1. Computational and Systems Biology
    2. Neuroscience

    A stochastic neuronal model predicts random search behaviors at multiple spatial scales in C. elegans

    William M Roberts, Steven B Augustine ... Shawn R Lockery
    A stochastic model of locomotory control in C. elegans based on an extensive new set of tracking data can explain and predict effects of ablations and mutations on behavior.
    1. Cell Biology
    2. Computational and Systems Biology

    From actin waves to mechanism and back: How theory aids biological understanding

    Carsten Beta, Leah Edelstein-Keshet ... Arik Yochelis
    Mathematical methods reveal common underlying principles in diverse models of intracellular actin waves.
    1. Neuroscience

    Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation

    Travis A Hage, Alice Bosma-Moody ... Gabe J Murphy
    A combination of multicellular recording and optogenetic photostimulation was used to deeply characterize the spatial profiles and effective strengths of intralaminar and translaminar synaptic connections from genetically defined neuronal populations in the visual cortex of adult mouse.
    1. Neuroscience

    How many neurons are sufficient for perception of cortical activity?

    Henry WP Dalgleish, Lloyd E Russell ... Michael Häusser
    Targeted optogenetic activation of small ensembles of neurons is sufficient to trigger a behavioral report while recruiting matched network suppression, suggesting exquisite sensitivity despite network mechanisms that maintain sparseness.
    1. Cell Biology
    2. Neuroscience

    Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

    Shataakshi Dube O'Neil, Bence Rácz ... Scott H Soderling
    Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.
    1. Neuroscience

    Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN

    Martin A Spacek, Davide Crombie ... Laura Busse
    Electrophysiology and optogenetic circuit manipulation in the mouse visual system reveal that corticothalamic feedback and behavioral state both have robust modulatory, yet largely independent influences on thalamic responses to naturalistic movies.
    1. Cell Biology

    Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

    Tae Yeon Yoo, Jeong-Mo Choi ... Daniel J Needleman
    Quantitative experiments and theory show that the tension-dependent regulation of NDC80 binding to kinetochore microtubules arises from a combination of the changing Aurora B concentration at NDC80 and the nonlinearity of Aurora B autoactivation.
    1. Neuroscience

    Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctions

    Shigeki Watanabe, Qiang Liu ... Erik M Jorgensen
    Optogenetics has revealed that synaptic vesicles can be recycled extremely rapidly in nematodes, indicating that existing models for how synapses 'reload' may need to be revised.
    1. Neuroscience

    Most primary olfactory neurons have individually neutral effects on behavior

    Tayfun Tumkaya, Safwan Burhanudin ... Adam Claridge-Chang
    Of the 50 primary olfactory channels in vinegar flies, only 10 drive avoidance or approach behavior when activated by themselves, indicating that most olfactory responses are multi-channel responses that follow complex combination rules.

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