A map of the entire array of cell types and potential projections in the mushroom body of the fruit fly brain provides insights into the circuitry that supports learning of stimulus-reward and stimulus–punishment associations.
As the first fully genetically encoded method, PARIS allows cell-specific, long-term, repeated measurements of gap junctional coupling with high spatiotemporal resolution, facilitating its study in both health and disease.
The structures of photosystem II, with the water-oxidizing Mn4CaO5-cluster fully removed and in an intermediate assembly state, show that photoassembly is facilitated by perfectly pre-arranged protein ligands of the five metal ions.
Jose A Fernandez-Leon, Douglas S Engelke ... Fabricio H Do Monte
A combination of electrophysiological and optogenetic approaches revealed a causal role for glutamatergic neurons in the prelimbic cortex in regulating individual differences in decision-making strategies during a threat-avoidance vs. reward-approach conflict paradigm in rats.
Fabian Wehnekamp, Gabriela Plucińska ... Don C Lamb
The ability to follow single objects in 3D in a living organism with high spatiotemporal resolution opens new possibilities for quantitative biophysical studies of complex systems in their physiological context.
Elin Claesson, Weixiao Yuan Wahlgren ... Sebastian Westenhoff
Time-resolved crystallography provides insight into the photochemical reactions in photoreceptor proteins, explaining the earliest steps of how plants, fungi and bacteria sense red light.
The mechanism of signaling receptor delivery to primary cilia involves a specific cellular role of a Rab protein that is critical for vertebrate development.
Spatially and temporally patterned activation of the small GTPase Rho1 indicates that ventral-specific factors contribute to cell- and tissue-level behaviors during ventral furrow formation, the first step in Drosophila gastrulation.
