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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex

    Jordan D Carelli et al.
    An ancient complex comprising the eukaryotic elongation factor-1A and aminoacylated tRNA is shown to be the target of a cyclic heptapeptide and two unrelated natural products with potent anticancer activity.
    1. Microbiology and Infectious Disease

    Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase

    Tobias Geiger et al.
    Biochemical analyses and the crystal structure of TtsA reveal fundamental insight into the mechanisms by which this muramidase recognizes its peptidoglycan substrate to facilitate typhoid toxin secretion.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

    Xiaoke Chi et al.
    The C-terminal membrane binding domain of Bim is shown to interact with and activate Bim enabling it to kill cells not dependent on anti-apoptotic proteins for survival.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

    James Lee et al.
    Outer membrane β-barrel proteins in Gram-negative bacteria are assembled within the lumen of the BamA β-barrel.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Reconstitution of bacterial autotransporter assembly using purified components

    Giselle Roman-Hernandez et al.
    A complex that catalyzes the membrane integration of β barrel proteins and a molecular chaperone promote the complete assembly of a bacterial virulence factor in vitro.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

    Mohammed Jamshad et al.
    The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Coincidence detection and bi-directional transmembrane signaling control a bacterial second messenger receptor

    Richard B Cooley et al.
    Building on previous work (Chatterjee et al., 2014), the mechanism of coincidence detection in bacterial second messenger signaling across membranes is revealed at a molecular level, providing insight into the regulation of a conserved transmembrane receptor.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10

    Jingxiang Li et al.
    Transient interactions between NleE and PMSD10 suppress PSMD10 interaction with ATG7 to attenuate host autophagosome formation.
    1. Neuroscience

    Optocontrol of glutamate receptor activity by single side-chain photoisomerization

    Viktoria Klippenstein et al.
    Introduction of single photoswitchable unnatural amino acid into a neuronal receptor provides reversible, rapid and robust control of its activity by light, representing an important contribution to the fast expanding field of optopharmacology.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiple selection filters ensure accurate tail-anchored membrane protein targeting

    Meera Rao et al.
    Biochemical dissections show that the Guided Entry of Tail Anchored proteins (GET) pathway selects ER-destined tail-anchored proteins using at least two distinct molecular mechanisms, each recognizing a distinct physicochemical feature in the substrate.