149 results found
    1. Developmental Biology and Stem Cells
    2. Chromosomes and Gene Expression

    Natural variation in stochastic photoreceptor specification and color preference in Drosophila

    Caitlin Anderson et al.
    Binding site affinity and transcription factor levels are finely tuned in nature to regulate stochastic expression, setting the ratio of alternative photoreceptor fates and determining color preference.
    1. Cell Biology
    2. Human Biology and Medicine

    Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

    Ling Luo et al.
    The eye produces a protein that inhibits the growth of blood vessels in the deep retina, which includes the photoreceptor layer, and disruption of this process can lead to blindness.
    1. Cell Biology
    2. Neuroscience

    Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

    Toshihide Kurihara et al.
    Mouse models in which hypoxia can be genetically triggered in retinal pigmented epithelial cells show that hypoxia-induced metabolic stress alone can lead to photoreceptor atrophy/dysfunction.
    1. Computational and Systems Biology
    2. Neuroscience

    Microsaccadic sampling of moving image information provides Drosophila hyperacute vision

    Mikko Juusola et al.
    New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.
    1. Genetics and Genomics
    2. Neuroscience

    Co-expression of xenopsin and rhabdomeric opsin in photoreceptors bearing microvilli and cilia

    Oliver Vöcking et al.
    The recently characterized opsin group of xenopsins is likely a major player in animal eye evolution and may have been present in an ancient, highly plastic eye photoreceptor cell type.
    1. Neuroscience

    The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling

    Drew Stenesen et al.
    Fly vision depends on a member of the SLC22 transporter family for recycling the histamine neurotransmitter following its uptake by glia and its modification into the transport metabolite carcinine.
    1. Developmental Biology and Stem Cells

    Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina

    Brent S Wells et al.
    TGFβ family members instruct a cell fate decision downstream of stochastic signaling in the Drosophila retina to ensure correct pairing between different color photoreceptors for color vision.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds

    Matthew B Toomey et al.
    Birds that see ultraviolet light tune the sensitivity of their short-wavelength photoreceptors with colored filters to maximize the number of colors they can see.
    1. Developmental Biology and Stem Cells
    2. Chromosomes and Gene Expression

    Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa

    Budd A Tucker et al.
    Skin cells from a patient with retinitis pigmentosa have been used to generate induced pluripotent stem cells, which could potentially form the basis of new treatments for this disease.
    1. Genetics and Genomics
    2. Neuroscience

    Evolution: The enigmatic xenopsins

    Detlev Arendt
    A new member of the family of light-sensitive proteins called opsins has stirred up our view of photoreceptors.
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