Retinoic acid signaling from Muller glia is necessary for cone photoreceptor survival in the peripheral retina and is sufficient to promote cone survival in the central retina during retinal degeneration.

Tools and resources to identify transcriptional regulators that create and maintain differences between photoreceptor subtypes.

Dominant mutations in Arl3, linked to inherited retinal dystrophy, disrupt the active Arl3-GTP ciliary gradient and cause a defect in rod photoreceptor nuclear migration that can be rescued by elevating ciliary Arl3 activity or reducing aberrant non-ciliary Arl3 activity.

The eye produces a protein that inhibits the growth of blood vessels in the deep retina, which includes the photoreceptor layer, and disruption of this process can lead to blindness.

High-throughput screening of over 6000 drugs using cells and retina tissue with a CEP290 ciliopathy mutation identified a small molecule, reserpine, which enhanced photoreceptor survival in retinal organoids and in a mouse disease model by partially restoring balance in proteostasis.

R7 photoreceptors require the endosomal protein Lost and Found to form stable connections only when this protein is also present in neurons that are synaptic partners of R7.

Ca2+ influx through Cav1.4 channels is required for the structural, but not the molecular organization of the rod photoreceptor synapse.

Binding site affinity and transcription factor levels are finely tuned in nature to regulate stochastic expression, setting the ratio of alternative photoreceptor fates and determining color preference.

The retina compensates for rod death and deteriorating cones to retain high-fidelity visual signaling to the brain.

In a zooplankton larva, ciliary and rhabdomeric photoreceptor cells work antagonistically to form a spectral depth gauge.