80 results found
    1. Cell Biology
    2. Neuroscience

    Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

    Toshihide Kurihara et al.
    Mouse models in which hypoxia can be genetically triggered in retinal pigmented epithelial cells show that hypoxia-induced metabolic stress alone can lead to photoreceptor atrophy/dysfunction.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

    Mark A Kanow et al.
    Metabolic relationships between cells in the retina and retinal pigment epithelium are fundamental to retinal function, retinal disease and age-related vision loss and they may provide strategies for metabolism-based therapies.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

    Anna Plana-Bonamaisó et al.
    The nucleotide sensing ability of IMPDH1 at the Bateman domain is regulated by light-dependent phosphorylation in the retina, to adjust GTP synthesis to illumination conditions.
    1. Cell Biology
    2. Human Biology and Medicine

    Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

    Ling Luo et al.
    The eye produces a protein that inhibits the growth of blood vessels in the deep retina, which includes the photoreceptor layer, and disruption of this process can lead to blindness.
    1. Cell Biology
    2. Ecology

    The Natural History of Model Organisms: From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature

    Severin Sasso et al.
    Dubbed the 'green yeast', the model alga C. reinhardtii has profoundly advanced many areas of biology, but much remains to be learnt about its life in the wild.
    1. Cell Biology
    2. Human Biology and Medicine

    Ophthalmology: Keeping blood vessels out of sight

    Dawn Sim, Marcus Fruttiger
    Insight
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    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

    Aaron M Allen et al.
    A single-cell atlas of the adult fly VNC charts the types and properties of cells for future studies of brain development and function.
    1. Developmental Biology

    Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons

    Jiangnan Luo et al.
    Afferent-derived factors control the elaboration of appropriate and robust sizes of dendritic arbors by dynamically modulating dendritic growth parameters.
    1. Neuroscience

    Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

    Matthew CW Oswald et al.
    Reactive oxygen species, previously considered damaging agents linked to pathology, are required for normal neuronal plasticity, including adjustment of synaptic terminal size, maintenance of synaptic physiology and adaptive behavioural responses.
    1. Developmental Biology
    2. Neuroscience

    Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior

    Einav Wircer et al.
    Experiments in zebrafish reveal a new role for a critical hypothalamic transcription factor, orthopedia, in controlling developmental neuropeptide balance in a discrete oxytocin-producing neuronal circuit whose disrupted development affects social behavior.

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