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Area 2 of primary somatosensory cortex encodes kinematics of the whole arm
Raeed H Chowdhury et al.
Area 2 of somatosensory cortex represents kinematic details of the entire arm during movement, but this mapping from limb state to neural activity differs for reaching and passive limb displacement.
Two FGFRL-Wnt circuits organize the planarian anteroposterior axis
M Lucila Scimone et al.
Single-cell RNA sequencing identifies an adult regional gene expression map in planarian muscle that includes two FGFRL-Wnt circuits controlling head and trunk tissue pattern.
Synchronized amplification of local information transmission by peripheral retinal input
Pablo D Jadzinsky, Stephen A Baccus
Peripheral retinal input transiently amplifies information transmission from ganglion cells, dynamically allocating the resources of neural activity to times of expected high information content.
Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein
Stephan Heermann et al.
The lens-averted domains of the optic vesicle are reservoirs of neuroretinal cells that flow into the developing optic cup in a process that is critically influenced by BMP signaling.
A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice
Ana S Machado et al.
Analysis of 3D paw kinematics and whole-body coordination in freely walking mice isolates specific features of gait ataxia and supports the hypothesis that the cerebellum provides an internal forward model for motor control.
Structural Biology and Molecular Biophysics
C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor
Anthony W Azevedo et al.
Serine and threonine phosphorylation sites work in concert to provide rapid and reproducible desensitization of the G-protein coupled receptor rhodopsin.
A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in
Joana Torres et al.
A previously unknown oncogenic feature of an embryonic transcription factor was uncovered from transcriptomic analysis of tumors that lack functional Polycomb silencing.
Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
Dominique Förster et al.
The retinotectal map in zebrafish exhibits location-specific, functional specializations to match prey object movement in the visual field during the hunting sequence.
A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina
Christian Damsgaard et al.
A novel mode of oxygen delivery facilitated the adaptive evolution of vision in teleost fishes.
Stem Cells and Regenerative Medicine
Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration
Takashi Baba et al.
The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
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