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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Nanoscale protein architecture of the kidney glomerular basement membrane

    Hani Suleiman et al.
    High-resolution optical microscopy is used to reveal the organization of extracellular matrix proteins within the basement membrane of the blood filtration barrier in the kidney at the nanometer scale.
    1. Cell Biology
    2. Neuroscience

    Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

    Jose F Moruno-Manchon et al.
    G-quadruplex DNA regulates autophagy in neurons.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

    Suihan Feng et al.
    Caged, photoactivatible sphingosine localized to mitochondria permits demonstration of the importance of subcellular localization on lipid metabolism and signaling.
    1. Neuroscience

    Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

    Joan Font et al.
    Localized drug photoactivation provides light-mediated analgesia in behaving mice.
    1. Cell Biology
    2. Neuroscience

    Developmental mechanism of the periodic membrane skeleton in axons

    Guisheng Zhong et al.
    Super-resolution imaging reveals how the skeleton that supports the outer membrane of axons is assembled during development, and provides an explanation for why this structure preferentially forms in axons but rarely in dendrites.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein

    Mikel Garcia-Marcos et al.
    LOV2GIVe allows to activate Gi proteins non-invasively with innocuous blue light based on a design principle unrelated to light-activated GPCRs (metazoan opsins), thereby expanding the range of potential experimental applications.
    1. Neuroscience

    Optocontrol of glutamate receptor activity by single side-chain photoisomerization

    Viktoria Klippenstein et al.
    Introduction of single photoswitchable unnatural amino acid into a neuronal receptor provides reversible, rapid and robust control of its activity by light, representing an important contribution to the fast expanding field of optopharmacology.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains

    Huaying Zhao et al.
    Members of kainate and AMPA families of glutamate receptors exhibit large differences in affinity for homo- and hetero-dimerziation of their amino terminal domains, which may control gating characteristics and ion selectivity of receptor subtypes with different subunit composition.
    1. Cell Biology

    Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

    Joanna P Rys et al.
    Cells control the spatial organization and signaling of TGFβ receptors at focal adhesions via a mechanically regulated mechanism to integrate biochemical and physical cues.
    1. Neuroscience

    A family of photoswitchable NMDA receptors

    Shai Berlin et al.
    Molecular engineering can generate light-sensitive NMDA receptors with specific subunit combinations.