35 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Quantitative insights into the cyanobacterial cell economy

    Tomáš Zavřel et al.
    Phototrophic growth laws are elucidated by combining computational modeling and experiments for quantitative evaluation of cellular physiology, morphology and proteome allocation across a wide range of light conditions.
    1. Cell Biology
    2. Computational and Systems Biology

    Self-establishing communities enable cooperative metabolite exchange in a eukaryote

    Kate Campbell et al.
    A eukaryotic cell model overcomes metabolic deficiencies within a complex, self-establishing community that enables the growth-relevant exchange of metabolic intermediates.
    1. Ecology
    2. Genetics and Genomics

    Education and Outreach: March Mammal Madness and the power of narrative in science outreach

    Katie Hinde et al.
    Hypothetical battles between animals can be used to interest the general public in biology.
    1. Genetics and Genomics

    Science Forum: The critical importance of vouchers in genomics

    Janet C Buckner et al.
    Geneticists should include links to and information about permanently preserved voucher specimens on genome databases and publications.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources

    Bram Cerulus et al.
    Live-cell microscopy and genome-wide screens reveal how slow transitions in metabolism can underlie metabolic memory, providing a model for organisms demonstrating similar history-dependent behaviour and routes to improve industrial microbes.
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov et al.
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A prion accelerates proliferation at the expense of lifespan

    David M Garcia et al.
    In its capacity to switch into a heritable, prionogenic form, a conserved RNA-modifying enzyme epigenetically alters fundamental growth, aging, and protein synthesis properties of eukaryotic cells.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

    Christoph Heier et al.
    An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.
    1. Computational and Systems Biology

    Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments

    Christopher A Jackson et al.
    Single cell expression data can be used to determine how regulatory transcription factors and target genes are connected, and is especially useful when studying transcription factors controlling heterogeneous cell states.
    1. Microbiology and Infectious Disease

    Strong inter-population cooperation leads to partner intermixing in microbial communities

    Babak Momeni et al.
    Simulations and experiments on systems containing two different populations of microorganisms show that interactions that benefit at least one of the populations can lead to communities with stable compositions, and that strong cooperation between two populations can lead to communities in which both populations are mixed together.

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