430 results found
    1. Microbiology and Infectious Disease
    2. Genetics and Genomics

    Dissection of the in vitro developmental program of Hammondia hammondi reveals a link between stress sensitivity and life cycle flexibility in Toxoplasma gondii.

    Sarah L Sokol et al.
    A derived stress response trait may have contributed to the emergence of a globally dominant and promiscuous parasite.
    1. Ecology

    First bone-cracking dog coprolites provide new insight into bone consumption in Borophagus and their unique ecological niche

    Xiaoming Wang et al.
    Fossilized feces (coprolites) of extinct bone-crushing dogs, Borophagus parvus, from late Miocene (6 million years ago) of California demonstrates consumption and preservation of bones in digestive tracts and potential social hunting behavior by these predators.
    1. Developmental Biology and Stem Cells

    Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock

    Laura Lleras Forero et al.
    In contrast to amniotes, zebrafish (ray-finned fish, teleost) centra are formed from specialised notochord sheath cells, and the segmental patterning of these cells is independent of the segmentation clock.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A conserved function for pericentromeric satellite DNA

    Madhav Jagannathan et al.
    Satellite DNA mediates clustering of multiple chromosomes via formation of chromocenter to encapsulate the full complement of the genome into a single nucleus.
    1. Evolutionary Biology

    Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis

    Courtney W Stairs et al.
    A number of microbial eukaryotes have adapted to low oxygen conditions by acquiring a gene that allows their mitochondrial electron transport chain to continue to function when oxygen is scarce.
    1. Microbiology and Infectious Disease

    Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins

    Nitzan Koppel et al.
    A unique, widely distributed gut bacterial enzyme selectively metabolizes plant-derived cardiac glycoside drugs.
    1. Evolutionary Biology

    Silencing of transposable elements may not be a major driver of regulatory evolution in primate iPSCs

    Michelle C Ward et al.
    Human and chimpanzee-induced pluripotent stem cells show limited species-specificity in transposable element silencing.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

    Elena Khazina, Oliver Weichenrieder
    Human LINE-1 retrotransposition is found to critically depend on the rapidly evolving N-terminal sequence of the LINE-1 ORF1 protein and on the metastability of its coiled coil domain, indicating uncharacterized steps in LINE-1 retrotransposition.
    1. Cell Biology
    2. Computational and Systems Biology

    Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins

    Alex X Lu et al.
    100,000s of images from different growth conditions and genetic backgrounds can be integrated into proteome-scale analysis.

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