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    1. Developmental Biology
    2. Evolutionary Biology

    Bichir external gills arise via heterochronic shift that accelerates hyoid arch development

    Jan Stundl et al.
    Unique heterochrony in the cranial segments in bichirs triggers the early formation of their external gills, and might be informative about developmental mechanisms facilitating increased breathing capacity.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Learning protein constitutive motifs from sequence data

    Jérôme Tubiana et al.
    A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.
    1. Cancer Biology
    2. Developmental Biology

    A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion

    Katarina Valoskova et al.
    T antigen glycosylation, which marks metastatic cancer cells, is modulated on a small set of proteins by a conserved multipass transmembrane protein to allow tissue invasion by Drosophila macrophages.
    1. Developmental Biology
    2. Evolutionary Biology

    The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning

    Suparna Ray et al.
    mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Long-term balancing selection drives evolution of immunity genes in Capsella

    Daniel Koenig et al.
    Retention of genetic diversity at immune-related loci drives the pattern of genetic variation in selfing Capsella.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Extensive transmission of microbes along the gastrointestinal tract

    Thomas SB Schmidt et al.
    Microbial populations are continuous along the gastrointestinal tract, with increased transmission in colorectal cancer and rheumatoid arthritis patients.
    1. Stem Cells and Regenerative Medicine

    Philosophy of Biology: Towards a classification of stem cells

    Lucie Laplane, Eric Solary
    The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.
    1. Plant Biology

    Multiple pairs of allelic MLA immune receptor-powdery mildew AVRA effectors argue for a direct recognition mechanism

    Isabel ML Saur et al.
    Allelic MLA immune receptors have an exceptional propensity to directly detect sequence-unrelated pathogen effectors and this feature might have facilitated functional diversification of the receptor in the host population.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

    Carolina Alvadia et al.
    While activated by a common mechanism, both functions in TMEM16F - lipid scrambling and ion conduction - are likely mediated by alternate protein conformations that are at equilibrium in the ligand-bound state.
    1. Cancer Biology
    2. Computational and Systems Biology

    Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

    Anna S Trigos et al.
    Cancer is a consequence of the release of basal cellular functions inherited from our unicellular ancestors from the control of regulatory networks that evolved during the emergence of multicellularity.