Unique heterochrony in the cranial segments in bichirs triggers the early formation of their external gills, and might be informative about developmental mechanisms facilitating increased breathing capacity.
mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.
Allelic MLA immune receptors have an exceptional propensity to directly detect sequence-unrelated pathogen effectors and this feature might have facilitated functional diversification of the receptor in the host population.
While activated by a common mechanism, both functions in TMEM16F - lipid scrambling and ion conduction - are likely mediated by alternate protein conformations that are at equilibrium in the ligand-bound state.
Cancer is a consequence of the release of basal cellular functions inherited from our unicellular ancestors from the control of regulatory networks that evolved during the emergence of multicellularity.