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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating influenza antigenic dynamics with molecular evolution

    Trevor Bedford et al.
    Combined antigenic and genetic analysis shows that different strains of the human influenza virus display dramatically different rates of antigenic drift, and that these differences have a significant impact on the number of new infections in each flu season.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples

    Feiqiao Brian Yu et al.
    Microfluidic-based mini-metagenomics enables the investigation of environmental microbial communities in high-throughput and with single-cell resolution, facilitating genome binning and quantification of function, abundance, and genome variation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Pan-mammalian analysis of molecular constraints underlying extended lifespan

    Amanda Kowalczyk et al.
    Cancer control, DNA repair, and immunity are key functionalities underlying the evolution of extended lifespan in mammals.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

    Bargavi Thyagarajan, Jesse D Bloom
    Deep mutational scanning was used to comprehensively quantify the effects of mutations to influenza hemagglutinin and shows that the virus possesses a high inherent mutational tolerance at key antigenic sites.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Emergence and evolution of an interaction between intrinsically disordered proteins

    Greta Hultqvist et al.
    The resurrection of ancient ancestral intrinsically disordered proteins reveals the evolution of a protein-protein interaction in molecular detail.
    1. Evolutionary Biology
    2. Plant Biology

    Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway

    Gaurav D Moghe et al.
    Integrative analysis of a specialized metabolic pathway across multiple non-model species illustrates mechanisms of emergence of chemical novelty in plant metabolism.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    An updated phylogeny of the Alphaproteobacteria reveals that the parasitic Rickettsiales and Holosporales have independent origins

    Sergio A Muñoz-Gómez et al.
    Diverse sophisticated phylogenetic analyses update the phylogeny of the Alphaproteobacteria and show that the parasitic Holosporales is a derived group within the Rhodospirillales order which comprises primarily free-living alphaproteobacteria.
    1. Evolutionary Biology

    Symptom evolution following the emergence of maize streak virus

    Adérito L Monjane et al.
    Phylogenetic analyses demonstrate an evolutionary trade-off between the amount of harm inflicted by a broad host-range virus and how effectively the virus positions itself within plants to enable onward transmission.
    1. Evolutionary Biology

    Convergent evolution of small molecule pheromones in Pristionchus nematodes

    Chuanfu Dong et al.
    Unexpected structural diversity of nematode small molecules, as revealed by high-resolution phylogenetic analysis, suggests recurrent biochemical innovation, a pattern that is probably typical across animals.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Origin and evolution of transporter substrate specificity within the NPF family

    Morten Egevang Jørgensen et al.
    Phylogenetic and biochemical analyses reveals a shared evolutionary path between biosynthesis and transport of defense metabolites in plants.