2,514 results found
    1. Physics of Living Systems

    Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila

    Myron Barber Child VI, Jack R Bateman ... Hernan G Garcia
    Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.
    1. Developmental Biology
    2. Physics of Living Systems

    Nuclear crowding and nonlinear diffusion during interkinetic nuclear migration in the zebrafish retina

    Afnan Azizi, Anne Herrmann ... William A Harris
    The evolving spatial distribution of nuclei between apical and basal surfaces of the developing retinal neuroepithelium is quantitatively described by a nonlinear diffusion equation accounting for crowding within the tissue.
  1. eLife Latest: One year of the Physics of Living Systems

    Approaches from the physical sciences are having an impact in biology.
    1. Computational and Systems Biology

    The genetic landscape of a physical interaction

    Guillaume Diss, Ben Lehner
    First comprehensive analysis of how many different mutations combine within and between two genes to alter a molecular phenotype.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Productivity loss associated with functional disability in a contemporary small-scale subsistence population

    Jonathan Stieglitz, Paul L Hooper ... Michael D Gurven
    Adult spinal fracture substantially impairs subsistence productivity, particularly for men.
    1. Physics of Living Systems

    Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics

    Andrea Giometto, David R Nelson, Andrew W Murray
    Like physical systems that exhibit nucleation phenomena, an invading population of a strong microbial antagonist requires a critical inoculum size to successfully invade a population of a weaker microbial antagonist.
    1. Medicine

    Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

    Sindre Lee-Ødegård, Marit Hjorth ... Kåre Inge Birkeland
    Long-term physical exercise had a substantial effect on the plasma proteome, identifying novel exerkines and suggesting CD300LG as a potential link to insulin sensitivity.
    1. Epidemiology and Global Health

    Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

    Ceereena Ubaida-Mohien, Sally Spendiff ... Russell T Hepple
    Skeletal muscle from world-class octogenarian athletes, representing a population with very high physical function in advanced age, exhibits greater mass and strength that is associated with overrepresentation of proteins involved in mitochondrial biology and more oxidatively competent muscle fibers.
    1. Plant Biology

    Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth

    Ivan Lebovka, Bruno Hay Mele ... Thomas Greb
    Radial plant growth produces large parts of terrestrial biomass and can be computationally simulated with the help of an instructive framework of intercellular communication loops.
    1. Biochemistry and Chemical Biology

    Ribozyme activity modulates the physical properties of RNA–peptide coacervates

    Kristian Kyle Le Vay, Elia Salibi ... Hannes Mutschler
    The physical properties of model coacervate protocells are modulated by the activity of an RNA ligase ribozyme, which confers resistance to growth, surface wetting, and material exchange, establishing a link between RNA sequence and protocell phenotype.

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