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Physics of Living Systems
Length regulation of multiple flagella that self-assemble from a shared pool of components
Thomas G Fai et al.
Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
Katherine Cora Ames, Mark M Churchland
Neurons in motor cortex contain information about each arm, but these signals are separated into different dimensions, allowing separate control of each arm.
Electrocorticographic dissociation of alpha and beta rhythmic activity in the human sensorimotor system
Arjen Stolk et al.
Direct cortical recordings in humans link the spectral structure of local field potentials to inhibition/disinhibition mechanisms coordinating sensorimotor neuronal populations during movement imagery.
An arbitrary-spectrum spatial visual stimulator for vision research
Katrin Franke et al.
Towards a community effort, we here present a flexible yet standardised visual stimulator design based on open hardware and software.
Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth
Samora Okujeni, Ulrich Egert
Activity-dependent neurite outgrowth and neuronal migration interact to shape modular mesoscale network architecture by homeostatic self-organization.
Structural Biology and Molecular Biophysics
Kinesin and dynein use distinct mechanisms to bypass obstacles
Luke S Ferro et al.
Dynein bypasses obstacles on microtubules more efficiently than single kinesin, and kinesins overcome this limitation when transporting intracellular cargos in teams.
A primal role for the vestibular sense in the development of coordinated locomotion
David E Ehrlich, David Schoppik
Zebrafish use their sense of gravity and their cerebellum to coordinate the fin and body movements that, as they develop, allow them to better maintain balance as they climb.
Computational and Systems Biology
Physics of Living Systems
Epistasis and entrenchment of drug resistance in HIV-1 subtype B
Avik Biswas et al.
Drug resistance in HIV is the result of mutations, which affect fitness depending on epistatic interactions with the entire sequence background that varies within and between patient populations.
A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome
Guanglin Xing et al.
Asparagine 88 to lysine (N88K), a prevalent congenital myasthenic syndrome mutation of Rapsyn, impairs the neuromuscular junction by disrupting agrin signaling.
Human Biology and Medicine
Stimulation of Piezo1 by mechanical signals promotes bone anabolism
Xuehua Li et al.
Mechanical stimuli activate Piezo1 in osteoblast lineage cells and thereby promote bone formation in part via Wnt1.
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