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    1. Neuroscience

    Misaligned feeding impairs memories

    Dawn H Loh et al.
    The time at which mice consume food can dramatically affect hippocampal-dependent biochemistry, physiology, and learned behavior.
    1. Cell Biology
    2. Developmental Biology

    Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions

    Amy E Brinegar et al.
    Global transcriptome changes, particularly alternative splicing, are highly dynamic the first 2 weeks after birth, and the example of calcineurin A splicing exemplifies the importance of alternative splicing during skeletal muscle development.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Quantitative insights into the cyanobacterial cell economy

    Tomáš Zavřel et al.
    Phototrophic growth laws are elucidated by combining computational modeling and experiments for quantitative evaluation of cellular physiology, morphology and proteome allocation across a wide range of light conditions.
    1. Chromosomes and Gene Expression

    Serotonin signaling mediates protein valuation and aging

    Jennifer Ro et al.
    Serotonin modulates diet-dependent lifespan in flies.
    1. Immunology and Inflammation
    2. Neuroscience

    Development and characterization of a chronic implant mouse model for vagus nerve stimulation

    Ibrahim T Mughrabi et al.
    Long-term, dose-controlled vagus nerve stimulation (VNS) is feasible in mice using a multi-lab validated implantation procedure, allowing therapeutic testing of VNS in many disease models.
    1. Neuroscience

    Monitoring ATP dynamics in electrically active white matter tracts

    Andrea Trevisiol et al.
    ATP imaging of spiking optic nerve axons in real time reveals correlation between ATP levels and electrical activity as well as contribution of lactate metabolism to axonal ATP homeostasis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Modulating FOXO3 transcriptional activity by small, DBD-binding molecules

    Judith Hagenbuchner et al.
    The mode of binding and cellular effect of the first FOXO3-DNA-binding-domain targeting small compound discovered by a combined pharmacophore-based/biochemical screening approach is reported.
    1. Neuroscience

    A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons

    Kristina D Micheva et al.
    Parvalbumin-positive inhibitory neurons in the cortex have insulating myelin sheathes, despite forming only short-range connections.
    1. Neuroscience

    Central processing of leg proprioception in Drosophila

    Sweta Agrawal et al.
    Proprioceptive signals about leg position, movement, and vibration are integrated in downstream circuits in the fly's central nervous system.
    1. Cell Biology
    2. Developmental Biology

    Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity

    Ayhan Atmanli et al.
    A novel live-cell mRNA imaging technology identifies individual living cells based on their gene expression and enables the concurrent study of their physiology.