24 results found
    1. Microbiology and Infectious Disease

    Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1

    Hongbing Jiang et al.
    Genetic and biochemical analyses identify a pathway important for infection by many picornaviruses.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

    Safia Deddouche et al.
    A viral RNA has been identified as a specific MDA5 agonist in cells infected with encephalomyocarditis virus.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Globally defining the effects of mutations in a picornavirus capsid

    Florian Mattenberger et al.
    Comprehensive analyses of how mutations in a picornavirus capsid affect viral fitness provide novel insights into viral biology, evolution, and host interactions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse viral proteases activate the NLRP1 inflammasome

    Brian V Tsu et al.
    Proteases from diverse viruses, the first described pathogen-encoded activators of human NLRP1, cleave NLRP1 at a sequence that mimics the viral polyprotein, resulting in inflammasome activation and pro-inflammatory cytokine release.
    1. Microbiology and Infectious Disease

    Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses

    Efraín E Rivera-Serrano et al.
    Quasi-enveloped hepatitis A virions undergo clathrin-mediated endocytosis, followed by ALIX-dependent trafficking to lysosomes where the quasi-envelope is degraded, triggering uncoating of the RNA genome in association with lysosomal membrane rupture.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

    Donna L Mallery et al.
    The inositol phosphate IP6 is selectively packaged into HIV virions, where it coordinates electropositive pores in the capsid to prevent spontaneous collapse and promote encapsidated DNA synthesis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry

    Jelke Jan Fros et al.
    RNA virus replication is attenuated by an intrinsic restriction mechanism after introducing CpG/UpA dinucleotides into both non-translated and coding regions of viral genomes, which may be exploited in the design of attenuated virus vaccines.
    1. Microbiology and Infectious Disease

    RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

    Fiona Tulloch et al.
    Attenuating candidate live virus vaccines by incorporating unfavoured codon pairs to reduce translation efficiency is actually mediated though changes in frequencies of CpG and UpA dinucleotides, which make viruses more visible to the innate immune system.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

    Zhaowei Wang et al.
    A picorna-like virus promotes the accumulation of caspase-cleaved drosophila inhibitor of apoptosis 1 by inducing the degradation of NTAN1, a key N-end rule degradation pathway component, leading to apoptosis inhibition and viral replication enhancement.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.

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