GABAergic postsynaptic responses mediated by spontaneous and evoked neurotransmitter release are partially segregated, suggesting they may serve distinct roles in neuronal signaling.

Proprioceptive signals about leg position, movement, and vibration are integrated in downstream circuits in the fly's central nervous system.

Altered activity of ATP-sensitive K⁺ channels underlies the metabolic seizure resistance produced by genetic manipulation of the BAD protein in mice.

Complex and distributed plasticity processes are revealed by a functional and pharmacological analysis of visual habituation learning in larval zebrafish.

Electrophysiology, optogenetics, and imaging in a mouse model of Dravet syndrome reveals dentate gyrus circuit dysfunction driven by hyperexcitability of the perforant path input from entorhinal cortex that can be modulated by recruitment of parvalbumin-expressing inhibitory interneurons.

Heterozygous Nf1 knockout mice exhibit distinct dopaminergic phenotypes in vivo, as revealed by the genetically encoded dopamine sensor dLight1, patch clamp electrophysiology, optogenetics, and novel viral tools for morphological analysis.

The ascidian Ciona integrates visual information from two photoreceptor types through convergent excitatory and disinhibitory circuits, thereby evoking swim behaviors.

Serotonin neurons in chronically isolated mice become less responsive to excitatory stimulation, but inhibiting a distinctive calcium-activated potassium channel can restore both neuronal activity and behavior.

The hyperpolarization-activated inward current plays an important role in regulating both smooth transitory responses and persistent increases in pyloric frequency during temperature fluctuations in Cancer borealis.

Experiments examining the actions of morphine on single neurons from one of the brain's reward centers, the VTA, reveal the mechanism by which the drug exerts its hedonic effects.