7,442 results found
    1. Microbiology and Infectious Disease

    Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs

    Chong Li, Marie R Culhane ... Montserrat Torremorell
    Vaccination has the potential to decrease swine influenza diversification by restricting influenza virus co-infections and reassortment events in pigs.
    1. Structural Biology and Molecular Biophysics

    PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

    Sergey Gorelick, Genevieve Buckley ... Alex de Marco
    The PIE-scope resolves the limitations in correlative cryo-focused ion beam milling by adding robustness and ease of use to the workflow.
    1. Cell Biology

    A single-cell transcriptome atlas of pig skin characterizes anatomical positional heterogeneity

    Qin Zou, Rong Yuan ... Yanzhi Jiang
    The heterogeneity in molecule and function of three main cell types of smooth muscle cells, endothelial cells, and fibroblasts from both different anatomical sites of pig skin was comprehensively exposited.
    1. Immunology and Inflammation

    Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

    Yong Miao, Jaya Bhushan ... Monika Vig
    Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
    1. Neuroscience

    Differential temporal dynamics during visual imagery and perception

    Nadine Dijkstra, Pim Mostert ... Marcel AJ van Gerven
    In contrast to perception, during visual imagery, there are no clear time-locked processing stages and imagery specifically overlaps with perceptual processing around 160 ms after stimulus onset and from 300 ms onwards.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen, Wen-Fu Hsieh ... Jun-An Chen
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Microbiology and Infectious Disease

    CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

    Kui Xu, Yanrong Zhou ... Kui Li
    The double-gene-knockout pig is a valuable model to help understand the mechanisms of CD163 and pAPN in the infection of multiple viruses and offers excellent breeding materials for disease-resistant pigs.
    1. Microbiology and Infectious Disease

    Bacillus velezensis HBXN2020 alleviates Salmonella Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation

    Linkang Wang, Haiyan Wang ... Ping Qian
    Bacillus velezensis has broad-spectrum antibacterial activity and can reduce the colonization of Salmonella Typhimurium in the intestinal tract of mice.
    1. Cell Biology

    An essential and NSF independent role for α-SNAP in store-operated calcium entry

    Yong Miao, Cathrine Miner ... Monika Vig
    α-SNAP mediated rearrangement of Stim1 and Orai1 molecules within CRAC channel clusters is required for store-operated calcium entry.
    1. Cell Biology

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius, Sam Virtue ... Antonio Vidal-Puig
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.

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