A comprehensive genome scan of 18,000 multi-ethnic individuals with 3-dimensional facial images highlighted multiple face-associated genetic loci for which regulatory activities in human neural cells were established.

Tricyclic antidepressants activate lysosomal two-pore Na⁺ channels in a voltage-dependent manner.

After developing a force-gliding assay with nanometer and piconewton precision, it is concluded that multiple kinesins driving a single cargo induces tension, resulting in smooth cargo transport, even with roadblocks.

Probe-Seq is a cell type specific bulk RNA sequencing method that can be applied to a wide-ranging tissue types from both vertebrates and invertebrates without genetic labeling.

A new deep-learning software toolkit with general-purpose methods for quickly and reliably measuring the full body posture of animals directly from images or videos without physical markers.

Genetic analysis of a CLN4 Drosophila model suggests that the disease-causing alleles act as dominant gain of function mutations that cause CSPα oligomerization and impair secretory and prelysosomal trafficking.

Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.

Rare, evolutionarily recent variants have larger effect sizes and are more likely to decrease fitness, providing evidence that quantitative traits in yeast have evolved under purifying selection.

Single-cell measurements combined with a new statistical framework for discriminating between models of cell cycle regulation show that chromosome initiation controls the E. coli cell cycle via two adder mechanisms.

Ventro-lateral prefrontal cortex codes novel rules starting from their first-time implementation right after instruction while early consolidation is channeled through increasing cooperation with the anterior striatum.