Crucial functions of Toll signalling during dorsoventral axis formation might have evolved convergently in flies and crickets.

Injuries activate the oral identity-specifying canonical Wnt signaling pathway in Hydra, which can trigger head regeneration in permissive tissue contexts created by the absence of pre-existing organizers.

Experiments in a mouse model for Alzheimer’s disease using germ-free and conventionally housed animals reveal that microbiota-derived short-chain fatty acids promote the deposition of cerebral Aβ plaques.

Cell competition is an important mechanism selecting against aneuploid cells.

Simultaneous multimodal measurement of chromatin accessibility, gene expression, and protein expression provides a unified view of the molecular underpinnings of immune cell state in health and disease.

Unbiased and automatic annotation using structured prediction framework with efficiently built data-driven atlases is more accurate than registration-based methods for cell identifications in dense images and enables fast whole-brain analysis.

'Cellular Electron Microscopy 500,000 images' (CEM500K) is a highly heterogeneous, information-rich, non-redundant, unlabeled EM dataset curated to pre-train DL algorithms for better model generalization on EM segmentation tasks.

Mutating a highly conserved intramembrane salt bridge unmasks structural and functional coupling between channel gating and ion permeation in the muscle nicotinic receptor.

3D reconstruction for an insect provides new internal structures at nanometer resolution, and the reconstructed feeding insect reveals unexpected contraction of stylet protractors and suggested a novel phloem sap-sucking model.

The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function sensitive to environmental challenges in Drosophila.