2,394 results found
    1. Evolutionary Biology

    Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population

    Khai C Ang, Victor A Canfield ... Keith C Cheng
    Analysis of 458 Kalinago provides new insights into the population's genetic structure, the contribution of Native American ancestry to skin pigmentation, and the identification of a coding variant in OCA2 with an estimated –8 melanin units effect size.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

    Bo Lu, Liting Dong ... Chengqi Yi
    Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
    1. Computational and Systems Biology
    2. Developmental Biology

    Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network

    Erik Clark, Michael Akam
    The organisation of the Drosophila embryo into segmental units is orchestrated by combinatorial regulatory interactions between spatially patterned and temporally patterned transcription factors.
    1. Cell Biology

    Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile

    Yoko Nakai-Futatsugi, Jianshi Jin ... Masayo Takahashi
    Pigmentation that confers protective function of RPE is not underlaid by a specific gene expression profile, reviled by microscopic imaging together with single-cell RNA sequencing.
    1. Plant Biology

    Accurate and versatile 3D segmentation of plant tissues at cellular resolution

    Adrian Wolny, Lorenzo Cerrone ... Anna Kreshuk
    Convolutional neural networks and graph partitioning algorithms can be combined into an easy-to-use tool for segmentation of cells in dense plant tissue volumes imaged with light microscopy.
    1. Developmental Biology

    Cell-autonomous timing drives the vertebrate segmentation clock’s wave pattern

    Laurel A Rohde, Arianne Bercowsky-Rama ... Andrew C Oates
    A noisy cell-intrinsic timer provides positional information for the segmentation clock, modulated by extrinsic factors such as FGF.
    1. Evolutionary Biology
    2. Neuroscience

    Mice and primates use distinct strategies for visual segmentation

    Francisco J Luongo, Lu Liu ... Doris Y Tsao
    The behavioral ability of mice and treeshrews to detect visual figures is highly texture dependent, unlike that of primates including macaques and mouse lemurs, and neural responses to figures in mouse visual cortex are similarly texture dependent.
    1. Epidemiology and Global Health

    A case study for a psychographic-behavioral segmentation approach for targeted demand generation in voluntary medical male circumcision

    Sema K Sgaier, Maria Eletskaya ... Steve Kretschmer
    A novel, hybrid segmentation technique reveals human heterogeneity in barriers towards a behavior, and is applied to characterize distinct segments in voluntary medical male circumcision.
    1. Cell Biology

    Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

    Christopher A Natale, Elizabeth K Duperret ... Todd W Ridky
    Two receptors have been identified that can be targeted in melanocytes with selective small molecule agonists to modulate human skin color.
    1. Structural Biology and Molecular Biophysics

    Streamlining segmentation of cryo-electron tomography datasets with Ais

    Mart GF Last, Leoni Abendstein ... Thomas H Sharp
    The software package Ais simplifies automated segmentation in cryo-electron tomography, enabling users to segment, detect particles, and visualize data in a streamlined and accessible workflow.

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